Selective acylation method

Details Selective acylation method Selective acylation method

1997-07-08

1999-05-18

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

530324, 530345, 530402, 514 3, A61K38/28

Patent

active

059051400

ABSTRACT:
A method of selectively acylating an insulin, an insulin analogue or a precursor thereof having a free .epsilon.-amino group of a Lys residue contained therein and at least one free .alpha.-amino group which method comprises reacting the .epsilon.-amino group with an activated amide in a polar solvent in the presence of a base.

REFERENCES:
patent: 3869437 (1975-03-01), Lindsay et al.
patent: 4369179 (1983-01-01), Rink et al.
patent: 5304473 (1994-04-01), Belagaje et al.
patent: 5646242 (1997-07-01), Baker et al.
Diaglog Information Services, Abstract 351, Accession No. 008078156, JP, A, 1254699.

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