Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-08-19
1999-12-07
Fredman, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 5, 435 29, 435 34, C12Q 168, C12Q 170, C12Q 102
Patent
active
059981369
ABSTRACT:
The present invention is directed to selection systems for the identification of cell proliferation genes based on functional analysis. More specifically, the invention is directed to a process for the identification of a cell proliferation promoting activity, the isolation of genes involved in such cell proliferation promoting activity, and the use of the so identified genes for the diagnosis or treatment of a disease associated with excessive cell proliferation. The invention further is directed to the design and development of antibodies, peptides, nucleic acids, and other compounds which specifically interfere with the function of the identified gene and/or its gene product, and pharmaceutical compositions comprising such compounds, for the treatment of diseases associated with inappropriate or unregulated cell proliferation.
REFERENCES:
patent: 5382510 (1995-01-01), Levine et al.
patent: 5811234 (1998-09-01), Roninson et al.
Li et al, "Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system", Science 262:1870-1874, Dec. 1993.
Knippschild et al, "Abrogation of wild-type p53 mediated growth inhibition by nuclear exclusion", Oncogene 12:1755-1765, Apr. 1996.
Muthukkumar et al, "Role of EGR-1 in thapsigargin inducible apoptosis in the melanoma cell line A375-C6", Mol. Cell. Biol. 15(11):6262-6272, Nov. 1995.
Bani et al, "Multiple features of advanced melanoma recapitulated in tumorigenic variants of early stage (radial growth phase) human melanoma cell lines: evidence for a dominant phenotype", Cancer Res. 56:3075-3086, Jul. 1996.
Abrahamson et al., 1995, "Regulation of p53-Mediated Apoptosis and Cell Cycle Arrest by Steel Factor", Mol. Cell. Biol. 15:6953-6960.
Arsura et al., 1995, "Variant Max Protein, Derived by Alternative Splicing, Associates with c-Myc In Vivo and Inhibits Transactivation", Mol. Cell. Biol. 15:6702-6709.
Bartel et al., 1995, "Analyzing Protein-Protein Interactions Using Two-Hybrid System", Methods Enzynol. 254:241-263.
Bishop, J.M. 1983, "Cellular Oncogenes and Retroviruses", Annu. Rev. Biochem. 52:301-354.
Bishop, J.M. 1987, "The Molecular Genetics of Cancer", Science 235:305-311.
Bourgeois et al, 1993, "Expression of an mdr Gene is Associated with a New Form of Resistance to Dexamethasone-Induced Apoptosis", Mol. Endocrinol. 7:840-851.
Cannon-Albright et al., 1992, "Assignment of a Locus for Familial Melanoma, MLM, to Chromosome 9p13-p22", Science 258:1148-1152.
Cavenee et al., 1983, "Expression of Recessive Alleles by Chromosomal Mechanisms in Retinoblastoma", Nature 305:779-784.
Chen et al., 1996, "Activation and Inhbition of the AP-1 Complex in Human Breast Cancer Cells", Mol. Carcinog. 15:215-226.
Cho et al., 1976, "Revertants of Human Cells Transformed by Murine Sarcoma Virus", Science 194:951-953.
Collins and Rivas, 1993, "The Control of Apoptosis in Mammalian Cells", TIBS 18:307-308.
Copeland et al., 1979, "Transformation of NIH/3T3 Mousel Cells by DNA of Rous Sarcoma Virus", Cell 17:993-1002.
Daub et al., 1996, "Role of Transactivation of the EGF Receptor in Signalling by G-protein-coupled Receptors", Nature 379:557-560.
Denko et al. 1995, "Mitotic and Post Mitotic Consequences of Genomic Instability Induced by Oncogenic Ha-Ras", Somat. Cell. Mol. Genet. 21:241-253.
Egawa et al., 1995, "Early Detection of Prostate Cancer", Cancer 76:463-472.
Evan et al., 1992, "Induction of APoptosis in FIbroblasts in c-myc Protein", Cell 69:119-128.
Fieck et al., 1992, "Modifications of the E.coli Lac Repressor for Expression in Eukaryotic Cells: Effects of Nuclear Signal Sequences on Protein Activity and Nuclear Accumulation", Nucleic Acid Res. 20:1785-1791.
Fischinger et al., 1972, "Reversion of Murine Sarcoma Virus Transformed Mouse Cells: Variants without a Rescuable Sarcoma Virus", Science 176:1033-1035.
Francke et al., 1976, "Retinoblastoma and Chromosome 13", Cytogenet. Cell Genet. 16:131-134.
Francke et al., 1979, "Aniridia-Wilms' Tumor Association: evidence for Specific Deletion of 11p13", Cytogenet. Cell Genet. 24:185-192.
Friend et al., 1986, "A Human DNA Segment with Properties of the Gene that Predisposes to Retinoblastoma and Osteosarcoma", Nature 343:643-646.
Friend et al., 1987, "Deletions of a DNA Sequence in Retinoblastomas and Mesenchymal Tumors: Organization of the Sequence and its Encoded Protein", Proc. Natl. Acad. Sci. U.S.A. 84:9059-9063.
Gaits et al., 1995, "Increase in Receptor-like Protein Tyrosine Phosphatase Activity and Expression Level on Density-dependent Growth Arrest of Endothelial Cells", Biochem. J. 311:97-103.
Galiana et al., 1995, "Indentification of a Neural-specific cDNA, NPDC-1, able to Down-regulate cell Proliferation and to Suppress Transformation", Proc. Natl. Acad. Sci. U.S.A. 92:1560-1564.
Gessler et al., 1990, "Homozyous Deletion in Wilms Turmors of a Zinc-finger Gene Identified by Chromosome Jumping", Nature 343:774-778.
Gossen and Bujard, 1992, "Tight Control of Gene Expression in Mammalian Cells by Tetracycline-responsive Promoters", Proc. Natl. Acad. Sci. U.S.A. 89:5547-5551.
Greenberger and Aaronson, 1974, "Morphologic Revertants of Murine Sarcoma Virus Transformed Nonproducer BALB/3T3: Selective Techniques for Isolation and Biologic Properties in Vitro and In VIvo", Virology 57:336-346.
Hall et al., 1990, "Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21", Science 250:1684-1689.
Harbour et al., 1988, "Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC", Science 241:353-357.
Harrington et al., 1994, "Oncogenes and Cell Death", Curr. Opin. Genet. Dev. 4:120-129.
Haslinger et al., 1985, "Upstream Promoter Element of the Human Metallothionein-11A Gene Can Act Like an Enhancer Element", Proc. Natl. Acad. Sci. U.S.A. 82:8572-8576.
Holt et al., 1996, "Growth Retardation and Tumour Inhibition by BRCA1", Nat. Genet. 12:298-302.
Horuk et al., 1993, "Purification, Receptor Binding Analysis, and Biiological Characterization of Human Melanoma Growth Stimulating Activity (MGSA)", J. Biol. Chem. 268:541-546.
Huang et al., 1988, "Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells", Science 242:1563-1566.
Inoue et al., 1983, "Rat Mutant Cells Showing Temperature Sensitivity for Transformation by WIld-type Moloney Murine Sarcoma Virus", Virology 125:242-245.
Itoh et al., 1991, "The polypeptide Encoded by the cDNA for Human Cell Surface Antigen Fas Can Mediate Apoptosis", Cell 66:233-243.
Johnson et al., 1995, "Selective Tumorigenesis in Non-parenchymal Liver Epithelial Cell Lines by Hepatocyte Growth Factor Transfection", Cancer Lett. 96:37-48.
Kamb et al., 1994, "A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types", Science 264:436-440.
Kashles et al., 1991, "A Dominant Negative Mutation Suppresses the Function of Normal Epidermal Growth Factor Receptors by Heterodimerization", Mol. Cell. Biol. 11:1454-1463.
Korsymeyer, 1992, "Bcl-2: A recpressor of Lymphocyte Death", Immunol. Today 13:285-288.
Kruglyak et al., 1995, "Complete Multipoint Sib-Pair Analysis of Qualitative and Quantitative Traits", Am. J. Hum. Genet. 57:439-454.
Kruglyak et al., 1995, "High-resolution Genetic Mapping of Complex Traits", Am. J. Hum. Genet. 56:1212-1223.
Kyprianou et al., 1991, "Programmed Cell Death During Regression of the MCF-7 Human Breast Cancer Following Estrogen Ablation", Cancer Res. 51:162-166.
Land et al., 1983, "Tumorigenic Conversion of Primary Embryo Fibrolblasts Requires at Least Two Cooperating Oncogenes", Nature 304:596-602.
Latif et al., 1993, "Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene", Science 260:1317-1320.
Lee et al., 1987, "The Retinoblastoma Susceptibility Gene Encodes a Nuclear Phosphoprotein Associated with DNA Binding Activity", Nature 329:642-645.
Lennon et al., 1996, "The I.M.A.G.E. Consortium: An Inegyrated Molecular Analysis of Genomes and Their Expression", Genomics 33:151-152.
Liang et al., 1995, "Analysis of ALtered Gene Expression by Differential Display", Methods Enzymol. 254:304-321.
Lin et al., 1992, "Growth Arrest Induced by Wild-t
Arcaris, Inc.
Fredman Jeffrey
Haley, Jr. James F.
Ruskin Barbara A.
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