Selection of target sites for antisense attack of RNA

Details Selection of target sites for antisense attack of RNA Selection of target sites for antisense attack of RNA

2007-12-25

2007-12-25

Shukla, Ram R. (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C435S004000, C435S006120, C702S020000, C702S027000

Reexamination Certificate

active

10478049

ABSTRACT:
Nucleic acid hybridization under steady-state conditions is described by a kinetic model in which the intermediate state is assumed to be locally single stranded. An expression was derived that relates nucleic acid secondary structure to the rate of oligonucleotide-RNA hybridization. The model allows the calculation of a rate factor that is proportional to the rate constant for hybridization between complementary nucleic acids and is generally applicable to any RNA molecule with potential utility for rapid identification of sites for antisense attack of mRNA.

REFERENCES:
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