Selection of ribozymes that efficiently cleave target RNA

Details Selection of ribozymes that efficiently cleave target RNA Selection of ribozymes that efficiently cleave target RNA

1992-08-18

1997-04-01

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 536 232, C12Q 170, C12Q 168, C07H 2102

Patent

active

056164599

ABSTRACT:
Mutant ribozymes are screened by culturing cells whose survival is dependant upon cleavage of RNA by a ribozyme, which cleavage causes the cells to survive in the presence of an agent which otherwise would kill the cells, and selecting cells which survive.

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