Selection media for beauveriolide I or beauveriolide III and...

Details Selection media for beauveriolide I or beauveriolide III and... Selection media for beauveriolide I or beauveriolide III and...

2005-06-07

2005-06-07

Lilling, Herbert J. (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

C435S076000, C435S116000, C435S120000

Reexamination Certificate

active

06902925

ABSTRACT:
The present invention is a process for selective production of beauveriolide I substance or beauveriolide III substance, in which a beauveriolide producing microorganism strain FO-6979 or mutant thereof is cultured in a medium for fungi added with specific amino acid in order to produce beauveriolide I substance or beauveriolide III substance selectively with high yield; beauveriolide I substance or beauveriolide III substance is accumulated selectively in the cultured mass; and beauveriolide I substance or beauveriolide III substance is collected selectively with high yield from said cultured mass.

REFERENCES:
patent: 11-279195 (1999-10-01), None
Ichiji Namatame et al., Beauveriolides, Specific Inhibitors of Lipid Droplet Formation in Mouse Macrophages, Produced by Beauveria sp. FO-6979, The Journal Of Antibiotics, vol. 52, No. 1, Jan. 1999.
Alexander Jegorov et al., Beauverolides L and La FromBeauveria tenellaandPaecilomyces fumosoroseus, vol. 37 No. 5 pp. 1301, 1303. 1994.
Keiko Mochizuki et al., The Structure of Bioactive Cyclodepsipeptides, Beauveriolides I and II, Metabolites of Entomopathogenic Fungi Beauveria sp., Bull Chem. Soc. Jpn, 66,3041-30465(1993).

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