Selecting animals for parentally imprinted traits

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S325000, C536S023100, C536S023500, C536S024310

Reexamination Certificate

active

09868732

ABSTRACT:
The invention relates to methods to select breeding animals or animals destined for slaughter for having desired genotypic or potential phenotypic properties, in particular related to muscle mass and/or fat deposition. The invention provides a method for selecting a pig for having desired genotypic or potential phenotypic properties comprising testing a sample from said pig for the presence of a quantitative trait locus (QTL) located at a Sus scrofa chromosome 2 mapping at position 2p1.7.

REFERENCES:
patent: 779393 (1998-12-01), None
patent: 98204291.3 (1998-12-01), None
patent: WO98/03682 (1998-01-01), None
patent: WO 00/36143 (2000-06-01), None
Pandya et al. (American Journal of Human Genetics 1994; 55(3) Suppl:A161).
Witkowski et al. (Biochem. 1999, 38:11643-11650).
Andersson-Eklund et al., “Mapping Quantitative Loci for Carcass and Meat Quality Traits in a Wild Boar x Large White Intercross,”J. Anim. Sci., vol. 76, 1998, pp. 694-700.
Kovács and Klöting, “Mapping of Quantitative Trait Loci for Body Weight on Chromosomes 1 and 4 in the Rat,” vol. 44, No. 2, Feb. 1998, pp. 399-405.
Johansson et al., “Comparative Mapping Reveals Extensive Linkage Conservation—but with Gene Order Rearrangements—between the Pig and the Human Genomes,”Genomics, vol. 25, 1995, pp. 682-690.
Reik et al., “Imprinting in Clusters: Lessons from Beckwith-Weidemann Syndrome,”Trends in Genetics, vol. 13, No. 8, 1997, pp. 330-334.
Catchpole and Engström, “Nucleotide Sequence of a Porcine Insuline-like Growth Factor II cDNA,”Nucleic Acids Research, vol. 18, No. 21, 1990, p. 6430.
Andersson et al., “Genetic Mapping of Quantitative Trait Loci for Growth and Fatness in Pigs,”Science, vol. 263, Mar. 25, 1994, pp. 1771-1774.
Knott et al., “Multiple Marker Mapping of Quantitative Trait Loci in a Cross Between Outbred Wild Boar and Large White Pigs,”Genetics, vol. 149, Jun. 1998, pp. 1069-1080.
Jeon et al., “A Paternally Expressed QTL Affecting Skeletal and Cardiac Muscle Mass in Pigs Maps to the IGF2 Locus,”Nat. Genet., vol. 21, Feb. 1999, pp. 157-158.
Nezer et al., “An Imprinted QTL with Major Effect on Muscle Mass and Fat Deposition Maps to the IGF2 Locus in Pigs”Nat. Genet., vol. 21, Feb. 1999 pp. 155-156.
Van Laere, et al., “A regulatory mutation in 1GF2 causes a major QTL effect on muscle growth in the pig,” Nature, Oct. 23, 2003, pp. 832-836, vol. 425.
De Vries, et al., “Gamatic imprinting effects on rate and composition of pig growth,” Theoretical and Applied Genetics, 1994, pp. 1037-1042, vol. 88.
Evidence in Support of the Opposition by Monsanto Technology LLC to Australian Patent Application Acceptance No. 779393 (Appln No. 27952/00) in the name of University of Liege, Melica HB and Seghersgentec N.V., dated Oct. 10, 2005 with Application for Extension of Time.
Statutory Delcaration of Bruce Stephan Wellington dated Oct. 7, 2005.
Knott et al., Multiple marker mapping of quantitative trait loci in a cross between outbred Wild Boar and Large White Pigs, Genetics, 1998, pp. 1069-1080, vol. 149 (previously listed and submitted for this application with IDS of Jul. 31, 2001).
Andersson et al., Genetic mapping of quantitative trait loci for growth and fatness in pigs, Science, 1994, pp. 1771-1774, vol. 263 (previously listed and submitted for this application with IDS of Jul. 31, 2001).
De Vries et al., Gametic imprinting effects on rate and composition of pig growth, Theoretical and Applied Genetics, 1994, pp. 1037-1042, vol. 88 (previously listed and submitted for this application with IDS of Dec. 27, 2005).
Dechiara et al., Parential imprinting of the mouse insulin-like growth factor II gene, Cell, 1991, pp. 849-859.
Statement of Grounds and Particulars in Support of Opposition, dated Jul. 15, 2005.
Notice of Opposition, dated Apr. 19, 2005.
Notice of Acceptance for Patent Application No. 27952/00 dated Jun. 12, 2004.
Moore et al., Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2, Proc. Natl. Acad. Sci., Nov. 1997, pp. 12509-12514, vol. 94.

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