Selecting animals for desired genotypic or potential...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Reexamination Certificate

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07732137

ABSTRACT:
The invention relates to methods to select animals, such as mammals, particularly domestic animals, such as breeding animals or animals destined for slaughter, for having desired genotypic or potential phenotypic properties, in particular, related to muscle mass and/or fat deposition lean meat, lean back fat, sow prolificacy and/or sow longevity. Provided is a method for selecting an animal for having desired genotypic or potential phenotypic properties comprising testing the animal, a parent of the animal or its progeny for the presence of a nucleic acid modification affecting the activity of an evolutionary conserved CpG island, located in intron 3 of an IGF2 gene and/or for the presence of a nucleic acid modification affecting binding of a nuclear factor to an IGF2 gene.

REFERENCES:
patent: WO 00/36143 (2000-06-01), None
patent: WO 00/36143 (2000-06-01), None
patent: WO 0036143 (2000-06-01), None
patent: WO 2004/063386 (2004-07-01), None
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#Caricasole et al., “Transactivation of mouse insulin-like growth factor II (IGF-II) gene promoters by the AP-1 complex.” Nucleic Acids Research. 1993. pp. 1873-1879. vol. 21. No. 8.
#Armarger et al., “Comparitive sequence analysis of the INS-IGF2-H19 gene cluster in pigs,” Mammalian Genome, 200. pp. 388-398. vol. 13.
#Van Laere et al.. “A regulatory mutataion in IGF2 causes a major QTL effect on muscle growth in the pig.” Nature. Oct. 23, 2003. pp. 832-836. vol. 425. No. 6960.

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