Selectin receptor modulating compositions

Details Selectin receptor modulating compositions Selectin receptor modulating compositions

1993-07-07

1996-06-18

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, 514 61, 536 21, A61K 31725, C08B 3710

Patent

active

055277853

ABSTRACT:
Selectin receptor binding is modulated by a method which utilizes heparin-like oligosaccharides.

REFERENCES:
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patent: 5208253 (1993-05-01), Boschelli et al.
patent: 5211937 (1993-05-01), Brandley et al.
patent: 5227369 (1993-07-01), Rosen et al.
patent: 5268364 (1993-12-01), Kojima et al.
R. M. Nelson et al. J. Clin. Invest., Mar. 1993, vol. 91, 1157-1116.
M. P. Bevilacqua et al. J. Clin. Invest., Feb. 1993, vol. 91, 379-387.
Assays for inhibitors of leukocyte adhesion Steven, et al., Chemical Abstracts, No. 9, 118:390, Mar. 1, 1993.
GMP-140 (P-selectin/CD62) binds to chronically stimulated but not resting CD4+T lymphocytes and regulates their production of proinflammatory cytokines Damle, et al., Eur. J. Immunol., 22:1789-1793, 1992.
Selectins Bevilacqua & Nelson, Perspectives, 91:379-387, Feb. 1993.
Characterization of Human Platelet GMP-140 as a Heparin-Binding Protein Skinner, et al., Biochemical & Biophysical Research Comm., No. 3, 164:1373-1379, Nov. 15, 1989.
GMP-140 Binding to Neutrophils Is Inhibited by Sulfated Glycans Skinner, et al., The Jrnl. of Biological Chemistry, No. 9, 266: 5371-5374, Mar. 25, 1991.
Degradation of Glycosaminoglycans and Fibronectin on Endotoxin-Stimulated Endothelium by Adherent Neutrophils: Relationship to CD11b/CH18 and L-Selectin . . . Klein, et al., The Jrnl. of Infect. Diseases, No. 4, 167:890-898, Apr. 1993.
Calcium-Dependent Heparin-Like ligands for L-Selectin in Nonlymphoid Endothelial Cells Norgard-Sumnicht, et al., Science, 261:480-483, Jul. 23, 1993.
Heparin Oligosaccharides bind L- and P-Selectin and Inhibit Acute Inflammation Nelson, et al., Blood, No. 11, 82:3253-3258, Dec. 1, 1993.

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