Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-02-18
1996-01-16
Schwartz, Richard A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530350, 530395, 435 72, C07K 1300, C07K 1514
Patent
active
054848911
ABSTRACT:
The invention relates to glycoprotein ligands of selectins. The invention further relates to methods and means for preparing and to nucleic acids encoding these ligands. The invention further concerns a method of treating a symptom or condition associated with excessive binding of circulating leukocytes to endothelial cells by administering to a patient in need of such treatment a glycoprotein ligand of a selectin.
REFERENCES:
Bevilacqua et al., Science 243:1160 (1989).
Bevilacqua et al., Proc. Natl. Acad. Sci. USA 84, 9238 (1989).
Berg et al., Immunol. Rev. 108, 5 (1989).
Bonfanti et al., Blood 73, 1109 (1989).
Bowen et al., J. Cell Biol. 109, 421 (1989).
Butcher, Am. J. Pathol. 136, 3 (1990).
Butcher, E. C., Curr. Top. Micro. Immunol. 128, 85 (1986).
Camerini et al., Nature 342(6245), 78 (1989).
Corral et al., Biochem. Biophys. Res. Commun. 172, 1349 (1990).
Duijvestijn and Hamann, Immunol. Today 10, 23 (1989).
Gallatin et al., Cell 44, 673 (1986).
Geng et al., Nature 343:757 (1990).
Geoffroy and Rosen, J. Cell. Biol. 109, 2463 (1989).
Goelz et al. Cell 63(6), 1349 (1990).
Hattori et al., J. Biol. Chem. 264(14), 7768 (1989).
Hession et al., Proc. Natl. Acad. Sci. USA 87(5), 1673 (1990).
Johnston et al., Cell 56, 1033 (1989).
Larsen et al. Cell 63, 467 (1990).
Lasky et al., Cell 56, 1045 (1989).
Lowe et al. Cell 63, 475 (1990).
McEver et al., J. Biol. Chem. 259, 9799 (1984).
Moore et al., J. Cell Biol. 112, 491 (1991).
Phillips et al., Science 250(4984), 1130 (1990).
Polley et al., Proc. Natl. Acad. Sci. USA 88, 6224 (1991).
Rosen et al., Science (Wash., D.C.) 228, 1005 (1985).
Rosen et al., J. Immunol. 142, 1895 (1989).
Siegelman et al., Science (Wash., D.C.) 243, 1165 (1989).
Siegelman et al., Proc. Natl. Acad. Sci. USA 86, 5562 (1989).
Stoolman, Cell 56, 907 (1989).
Stoolman et al., J. Cell Biol. 99, 1535 (1984).
Stoolman et al., Blood 70, 1842 (1987).
Tiemeyer et al. Proc. Natl. Acad. Sci. USA 88(4), 1138-42 (1991).
True et al., J. Cell Biol. 11, 2757-2764 (1990).
Walz et al. Science 250(4984), 1132 (1990).
Watson et al., J. Cell Biol. 110, 2221 (1990).
Watson et al., Nature 349, 164-167 (1991).
Woodruff et al., Annu. Rev. Immunol. 5, 201 (1987).
Yednock and Rosen, Adv. Immunol. 44, 313 (1989).
Gallatin et al., Nature 304, 30-34 (1983).
Stoolman and Rosen, J. Cell. Biol. 96, 722-729 (1983).
Tedder et al., J. Exp. Med. 170(1), 123-133 (1989).
Teder et al., J. Immunol. 144, 532-540 (1989).
Imai Yasuyuki
Lasky Laurence A.
Rosen Steven D.
Singer Mark S.
Dreger Ginger R.
Genentech Inc.
Guzo David
Schwartz Richard A.
The Regents of the University of California
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