Selectin ligand interactor cytoplasmic (SLIC-1), a...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

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07405272

ABSTRACT:
The invention provides isolated nucleic acids molecules, designated SLIC-1 nucleic acid molecules, which encode novel P-selectin glycoprotein ligand (PSGL-1) binding molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLIC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLIC-1 gene has been introduced or disrupted. The invention still further provides isolated SLIC-1 proteins, fusion proteins, antigenic peptides and anti-SLIC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

REFERENCES:
patent: 5843707 (1998-12-01), Larsen et al.
patent: WO 94/10309 (1994-05-01), None
patent: WO 00/58473 (2000-10-01), None
Attwood , Science 290: 471-473, 2000.
International Search Report, PCT/US01/09469, mailed Jan. 23, 2002.
Alonso-Lebrero et al., “Polarization and Interaction of Adhesion Molecules P-Selectin Glycoprotein Ligand 1 and Intercellular Adhesion Molecular 3 with Moesin and Ezrin in Myeloid Cells,”Blood, 95:2413-2419 (2000).
Bevilacqua et al., “Selectins,”J. Clin. Invest., 91:379-387 (1993).
Blanck et al., “Introduction of Selectin-Like Binding Specificity into a Homologous Mannose-Binding Protein,”J. Biol. Chem., 271:7289-7292 (1996).
Evangelista et al., “Platelet/Polymorphonuclear Leukocyte Interaction: P-selectin Triggers Protein-Tyrosine Phosphorylation-Dependent CD11b/CD18 Adhesion: Role of PSGL-1 as a Signaling Molecule,”Blood, 93:876-885 (1999).
Fersht, “Structure and Mechanism in Protein Science,” A guide to Enzyme Catalysis and Protein Folding, W.H. Freeman and Company (New York) 32-34 (1999).
Gyuris et al., “Cdi1, a Human G1 and S Phase Protein Phosphatase that Associates with Cdk2,”Cell, 75:791-803 (1993).
Harris et al., “A Novel Syndrome of Variant Leukocyte Adhesion Deficiency Involving Defects in Adhesion Mediated by Beta 1 and Beta 2 Integrins,”Blood, 97:767-776 (2001).
Hildt et al., “Identification of Grb2 as a Novel Binding Partner of Tumor Necrosis (TNF) Receptor I,”J. Exp. Med., 189:1707-1714 (1999).
Hidari et al., “Engagement of P-Selectin Glycoprotein Ligand-1 Enhances Tyrosine Phosphorylation ad Activates Mitogen-Activated Protein Kinases in Human Neutrohphils,”J. Biol. Chem., 272:28750-28756 (1997).
Insug et al., “Role of SA-Le(a) and E-Selectin in Metastasis Assessed with Peptide Antagonist,”Peptides, 23:999-1010 (2002).
Kogan et al., “A Single Amino Acid Residue Can Determine the Ligand Specifity of E-selectin,”J. Biol. Chem., 270: 14047-14055 (1995).
Kricka, “Ligand-Binder Assays: Labels and Analytical Strategies,” Marcel Dekker, Inc. 1-3 (1985).
Kuntz, “Structure-Based Strategies For Drug Design and Discovery,”Science, 257:1078-1082 (1992).
Lowe et al., “Therapeutic Inhibition of Carbohydrate-Protein Interactions In Vivo,”J. Clin. Invest., 99:822-826 (1997).
McEver et al., “Role of PSGL-1 Binding to Selectins in Leukocyte Recruitment,”J. Clin. Invest., 100:485-491 (1997).
Ngo et al., “In the Protein Folding Problem and Tertiary Structure Prediction,”Merz et al. (Ed), Birkhauser, Boston, MA pp. 433, 492-495 (1994).
XP002186368 Abstract “Sequencing of human chromosome 16.Homo sapienschromosome 16 clone RP11-401P9,” EMBL online database, Accession No. AC007608 (1999).
Ngo et al., “In the Protein Folding Problem and Tertiary Structure Prediction,”Merzet al. (Ed) , Birkhauser, Boston, MA pp. 433, 492-495 (1994).
Sako et al., “Expression Cloning of a Functional Glycoprotein Ligand for P-Selectin,”Cell, 75:1179-1186 (1993).
Schievella et al., “MADD, a Novel Death Domain Protein that Interacts with the Type 1 Tumor Necrosis Factor Receptor and Activates Mitogen-Activated Protein Kinase,”J. Biol. Chem., 272:12069-12075 (1997).
Skolnick et al., “From Genes to Protein Structure and Function: Novel Applications of Computational Approaches in the Genomic Era,”Trends Biotech., 18:34-39 (2000).
Snapp et al., “The Cytoplasmic Tail of P-Selectin Glycoprotein Ligand-1 (PSGL-1) is Required for Optimal Interactions with P-Selectin,”FASEB J., 14:A1146 (2000).
Varki et al., “Selectin Ligands: Will the Real Ones Please Stand Up,”J. Clin. Invest., 99:158-162 (1997).
XP002186366 Abstract “zs89a11.r1 NCI CGAP GCB1 Homo sapiens cDNA clone IMAGE: 704636 5,” EMBL online database, HS1186915, Accession No. AA282390 (1997).
XP002186367 Abstract “Ui-H-Bl1-abs-e-09-o-UI.s1 NCI CGAP Sub3 Homo sapiens cDNA clone IMAGE: 2713048 3; mRNA sequence,” EMBL online database, Accession No. AW134842 (1999).
XP002186368 Abstract “Sequencing of human chromosome 16. Homo sapiens chromosome 16 clone RP11-401P9,” EMBL online database, Accession No. AC007608 (1999).

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