Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-06-06
1997-08-05
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 2, 514 8, 514 23, 536 111, 536 41, 536 172, 536 175, 536 187, A61K 3170, A61K 3803, C07H 1500
Patent
active
056542828
ABSTRACT:
Glyco-amino acids and glycopeptides having three-dimensionally stable configurations are described. These glyco-amino acids and glycopeptides have glycoside functional groups, such as fucose and analogues and derivatives thereof, covalently bound to an amino acid or peptide having a free carboxylic group or sulfate group in an orientation that facilitates the binding between these groups and selectin receptors. The present glyco-amino acids and glycopeptides may be used in the treatment of selectin-mediated disorders, such as inflammation, autoimmune disease and cancer.
REFERENCES:
patent: 4386026 (1983-05-01), Ponpipom et al.
patent: 4849513 (1989-07-01), Smith et al.
patent: 5143712 (1992-09-01), Brandley et al.
Lasky Science 1992, 258, 964-969.
Arnaout et al., Blood 75:1037 (1990).
Aruffo et al., Proc. Natl. Acad. Sci. USA, 84:8573 (1987).
Berg et al., J. Biol. Chem., 265:14869 (1991).
Bevilacqua et al., "Selectins", J. Clin. Invest., 91:379-387 (1993).
Bevilacqua et al., "Identification of an Inducible Endothelial-Leukocyte Adhesion Molecule," Proc. Natl. Acad. Sci. USA, 84:9238-1942 (1987).
Bevilacqua et al., "Endothelial Leukocyte Adhesion Molecule 1: An Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins," Science, 243:1160-1165 (1989).
Blackburn et al., J. Biol. Chem., 261:2873 (1986).
Brandley et al., "Cell-Surface Carbohydrates in Cell Recognition and Response," J. Leuk. Biology, 40:97-111 (1986).
Carlson et al., "A Greatly Improved Procedure for Ruthenium Tetraoxide Catalyzed Oxidations of Organic Compounds," J. Org. Chem., 46:3936-3937 (1981).
Coste et al., "Tetrahedron Letters", 31:205 (1990).
Foxall et al., "The Three Members of the Selectin Receptor Family Recognize a Common Carbohydrate Epitope, the Sialyl Lewis.sup.x Oligosaccharide," The Journal of Cell Biology, 117:895-902 (1992).
Fukuda et al., "Structure of a Novel Sialylated Fucosyl Lacto-N-nor-hexaosylceramide Isolated from Chronic Myelogenous Leukemia Cells," J. Biol. Chem., 261:2376-2383 (1986).
Fukushi et al., "Localization and Alteration of Mno-, DI-, and Trifucosyl .alpha.1--3 Type 2 Chain Structures During Human Embryogenesis and in Human Cancer," J. Exp. Med., 159:506-520 (1984).
Geoffroy et al., "Demonstration that a Lectin-Like Receptor (gp90.sup.MEL) Directly Mediates Adhesion of Lymphocytes to High Endothelial Venules of Lymph Nodes," J. Cell Biol., 109:2463-2469 (1989).
Gong et al., Nature, 343:757 (1990).
Green et al., "Preparation of Pentafluorphenyl Esters of FMOC Protected Amino Acids with Pentafluorophenyl Trifluoroacetate," Tetrahedron Letters, 31:5851-5852 (1990).
Hakomori et al., "Human Cancer-Associated Gangliosides Defined by a Monoclonal Antibody (IB9) Directed to Sialosyl.alpha.2-6 Galactosyl Residue: A Preliminary Note," Biochem. Biophys. Res. Comm., 113:791-798 (1983).
Handa et al., Biochem. Biophys. Res. Comm., 181:1223 (1991).
Hession et al., Proc. Natl. Acad. Sci. USA, 87:1673 (1990).
Larsen et al., Cell, 59:305 (1989).
Lasky et al., "Cloning of a Lymphocyte Homing Receptor Reveals a Lectin Domain," Cell, 56:1045-1055 (1989).
Liener et al., "The Lectins: Properties, Functions and Applications in Biology and Medicine," Academia (1986).
Lo et al., J. Immunol., 143:3325 (1989).
Lowe et al., "ELAM-1-Dependent Cell Adhesion to Vascular Endothelium Determined by a Transfected Human Fucosyltransferase cDNA," Cell, 63:475-484 (1990).
Magnani et al., "A Monoclonal Antibody-Defined Antigen Associated with Gastrointestinal Cancer is a Ganglioside Containing Sialylated Lacto-N-Fucopentaose II," J. Biol. Chem., 257:14365-14369 (1982).
Oldenburg et al., "Peptide Ligands for a Sugar-Binding Protein Isolated from a Random Peptide Library," Proc. Natl. Acad. Sci. USA, 89:5393-5397 (1992).
Oshand et al., Immunology Today, vol. 11(6), pp. 193-195 (1990).
Phillips et al., Science, 250:1130 (1990).
Polte et al., Nucleic Acids Res.,18:1083 (1990).
Sharon et al., "Lectins as Cell Recognition Molecules," Science, 246:227-234 (1989).
Spertini et al., "Regulation of Leukocyte Migration by Activation of the Leukocyte Adhesion Molecule-1 (LAM-1) Selectin," Nature, 349:691-694 (1991).
Springer et al., Nature, 346:425 (1990).
Swank-Hill et al., Anal. Biochem., 183:27 (1987).
Stoolman et al., Cell, 56:907 (1986).
Stoolman et al., "Possible Role for Cell-Surface Carbohydrate-Binding Molecules in Lymphocyte Recirculation," The Journal of Cell Biology, 96:722-727 (1983).
Tyrell et al., Proc. Natl. Acad. Sci. USA, 88:10372 (1991).
Waldmann, Science, vol. 252, pp. 1657-1662 (1991).
Walz et al., Science, 250:1132 (1990).
Watson et al., "Neutrophil Influx Into an Inflammatory Site Inhibited by a Soluble Homming Receptor-IgG Chimaera," Nature, 349:164-167 (1991).
Abbas Saeed Abdalla
Holme Kevin Ross
Levy Daniel Emil
Tang Peng Cho
Fonda Kathleen Kahler
Glycomed Incorporated
Kight John
LandOfFree
Selectin binding glycopeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Selectin binding glycopeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Selectin binding glycopeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1074865