Selected thieno[2,3-d]pyrimidines

Details Selected thieno[2,3-d]pyrimidines Selected thieno[2,3-d]pyrimidines

1977-08-22

1979-06-26

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544250, 544 91, 544 89, 2603322C, 424251, 42424851, 424275, C07D49504, C07D48704, A61K 31505

Patent

active

041593774

ABSTRACT:
2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yields thieno[2,3-d]pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate hypersensitivity reaction in mammals are N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]oxamic acid, ethyl 5,6,7,8-tetrahydro-4-oxo-4H-benzothieno[2,3-d][1,3]oxazine-2-carboxylate, and ethyl 3,4-dihydro-6-ethyl-4-oxothieno[2,3-d]pyrimidine-2-carboxylate.

REFERENCES:
patent: 3634427 (1972-01-01), Schweizer et al.
patent: 3974161 (1976-08-01), Althuis et al.
patent: 4054656 (1977-10-01), Temple, Jr.
Blaskiewicz, et al, Chemical Abstracts, vol. 84, 17412t (1976).
Devani, et al, Chemical Abstracts, vol. 85, 46566x (1976).
Robba, et al, Chemical Abstracts, vol. 85, 160014r (1976).

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