Selected recovery of proteins from fermentation broths

Details Selected recovery of proteins from fermentation broths Selected recovery of proteins from fermentation broths

1981-06-08

1984-01-17

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

204180P, 204180R, 204301, 424 85, 424177, 435 68, 435811, A23J 106, A23K 3704, C07G 700, G12P 2100

Patent

active

044263236

ABSTRACT:
A process is described for the selective recovery and/or concentration of a protein or a class of proteins from fermentation broth employing a combination of desalting and pH adjustment thereby causing the initial precipitation of unwanted proteins, again subjecting the resulting supernatant to another set of pH adjustment and desalting to cause the protein of interest to precipitate thereby obtaining a highly enriched fraction of the selected protein. Such a process will find use in the specific recovery of genetically engineered proteins from fermentation broths, e.g. interferon, insulin, growth hormone, etc.

REFERENCES:
patent: 3414651 (1968-12-01), Fantes
patent: 3975344 (1976-08-01), Schwartz
patent: 4168261 (1979-09-01), Edy
patent: 4257938 (1981-03-01), Hosoi et al.
patent: 4276140 (1981-06-01), Jain
patent: 4296025 (1981-10-01), Sugimoto
patent: 4321192 (1982-03-01), Jain
patent: 4322275 (1982-03-01), Jain

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