Selected quaternary ammonium salts of pilocarpine useful in redu

Details Selected quaternary ammonium salts of pilocarpine useful in redu Selected quaternary ammonium salts of pilocarpine useful in redu

1976-04-26

1977-12-06

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548336, A61K 31415, C07D23364

Patent

active

040617220

ABSTRACT:
Compounds of the formula: ##STR1## wherein R represents a member selected from the group consisting of a hydrogen atom, a C.sub.1 -C.sub.20 open chain or cyclo alkyl group, a C.sub.1 -C.sub.20 alkoxyalkyl group, a C.sub.1 -C.sub.20 alkanoyloxyalkyl group, a C.sub.1 -C.sub.20 haloalkyl group, a C.sub.1 -C.sub.20 carboxyalkyl group, a phenyl group, a naphthyl group and a substituted phenyl or naphthyl group, whose substituents are selected from the group consisting of a halogen atom, an O-C.sub.1 -C.sub.4 alkyl group, an O-C.sub.1 -C.sub.8 alkanoyl group, a nitro group, a carboxyl group, and a carboethoxy group; wherein R.sub.1 represents a C.sub.9 -C.sub.22 straight or branched alkyl group, a ##STR2## group, wherein R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are each selected from the group consisting of a hydrogen atom, a methyl group, or an ethyl group, and wherein R.sub.1 further represents a member selected from the group consisting of a C.sub.0 -C.sub.22 straight or branched alkyl ##STR3## group, wherein n in each occurrence and m represent an integer of from 0 to 22, and an ##STR4## group, wherein A represents a -(CH.sub.2 CH.sub.2 O).sub.p group, wherein the p represents an integer of from 0 to 22 and a cholic acid residue; and wherein X represents a member selected from the group consisting of a halogen atom, a methanesulfonate group, a fluorosulfonate group and a tosylate group, useful in reducing intraocular pressure in warm-blooded animals are disclosed.

REFERENCES:
patent: 3415929 (1968-12-01), Lachman et al.
patent: 3845201 (1974-10-01), Haddad et al.

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