Selected CGRP-antagonists process for preparing them and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S252130, C514S316000, C514S318000, C514S319000, C514S320000, C514S321000, C514S322000, C540S500000, C544S360000, C546S187000

Reexamination Certificate

active

11073341

ABSTRACT:
The present invention relates to substituted piperidines of general formulawherein A, B, D, E, X, R1and R2are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.

REFERENCES:
patent: 2004/0063735 (2004-04-01), Chaturvedula et al.
patent: 2004/0076587 (2004-04-01), Kruss et al.
patent: 2004/0192729 (2004-09-01), Rudolf et al.
patent: 2004/0204397 (2004-10-01), Chaturvedula et al.
patent: WO 03/104236 (2003-12-01), None
patent: WO 2004/000289 (2003-12-01), None
patent: WO 2004/063171 (2004-07-01), None
CAS abstract of US 2004/0204397 and US 2004/0063735. 2004.
Mallee et al.; Receptor Activity-Modifying Protein 1 Determines the Species Selectivity of Non-peptide CGRP Receptor Antagonists; The Journal of Biological Chemistry; vol. 227, No. 16, Apr. 19, 2002, pp. 14294-14298; The American Society of Biochemistry and Molecular Biology, Inc.

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