Sel-10 and uses thereof

Details Sel-10 and uses thereof Sel-10 and uses thereof

1997-07-24

2000-07-11

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 536 231, 530350, C12N 120, C07H 1700, C07K 1400

Patent

active

060871539

ABSTRACT:
This invention provides an isolated nucleic acid molecule which encodes a wildtype or mutated SEL-10. This invention also provides a purified wild-type SEL-10 protein or a purified mutated SEL-10 protein. This invention also provides a method for production of an antibody capable of binding to wild-type SEL-10 or mutated SEL-10 protein. This invention also provides an antibody capable of specifically binding to wild-type SEL-10 or mutated SEL-10. This invention also provides a transgenic animal comprising the isolated nucleic molecule encoding SEL-10. This invention also provides a method for identifying a compound which is capable of ameliorating Alzheimer's disease. This invention also provides a method for determining whether a compound is capable of ameliorating Alzheimer's disease. This invention further provides a method for identifying a compound which is capable of treating cancer. This invention also provides a method for determining whether a compound is capable of treating cancer. This invention also provides a method for identifying a suppressor or enhancer that affects lin-12 or sel-12 activity in the same manner as sel-10. This invention also provides a method for producing suppressors of a sel-10 allele. This invention also provides a method for reversing the malignant phenotype of cells. This invention also provides a pharmaceutical composition effective in ameliorating Alzheimer's disease and treating cancer and methods of using such a pharmaceutical composition.

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