sEH inhibitors and their use

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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Details

C544S198000, C544S208000, C544S209000, C514S245000

Reexamination Certificate

active

07994317

ABSTRACT:
The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme.

REFERENCES:
patent: 2004/0029902 (2004-02-01), Singh et al.
patent: 1464335 (2004-10-01), None
patent: WO2009049154 (2009-04-01), None
patent: WO2009049157 (2009-04-01), None
patent: WO2009049165 (2009-04-01), None
Dorrance, Phd., Et Al.: “An Epoxide Hydrolase Inhibitor, 12-(3-Adamantan-1-Yl-Ureido)Dodecanoic Acid (AUDA), Reduces Ischemic Cerebral Infact Size in Stroke-Prone Spontaneously Hypertensive Rats” Journal of Cardiovascular Pharmacology, Dec. 2005, vol. 46, No. 6, pp. 842-848.
Fornage, Et Al.: “The Soluble Epoxide Hydrolase Gene Harbors Sequence Variation Associated With Susceptibility to and Protection From Incident Ischemic Stroke” Human Molecular Genetics, 2005, vol. 14, No. 19, pp. 2829-2837.
Fretland, Et Al.: “Epoxide Hydrolases: Biochemistry and Molecular Biology”, Chemico-Biological Interactions. 2000; vol. 129, pp. 41-59.
Imig, Et Al.: “Soluble Epoxide Hydrolase Inhibition Lowers Arterial Blood Pressure in Angiotensin II Hypertension” Hypertension. 2002; vol. 39 (Part 2), pp. 690-694.
Imig, Et Al.: “An Orally Active Epoxide Hydrolase Inhibitor Lowers Blood Pressure and Provides Renal Protection in Salt-Sensitive Hypertension” Hypertension. 2005; vol. 46 (Part 2): pp. 975-981.
Imig, Et Al.: “Cardiovascular Therapeutic Aspects of Soluble Epoxide Hydrolase Inhibitors” Cardiovascular Drug Reviews. 2006; vol. 24, No. 2, pp. 169-188.
Inceoglu, Et Al.: “Inhibition of Soluble Epoxide Hydrolase Reduces LPS-Induced Thermal Hyperalgesia and Mechanical Allodynia in a Rat Model of Inflammatory Pain” Life Sciences. 2006; vol. 79, pp. 2311-2319.
Jones, P.D. Et Al.: “Synthesis and SAR of Conformationally Restricted Inhibitors of Soluble Epoxide Hydrolase” Bioorganic & Medicinal Chemistry Letters, Oct. 1, 2009, vol. 16, No. 19, pp. 5212-5216.
Jung, Et Al.: “Soluble Epoxide Hydrolase is a Main Effector of Angiotensin II-Induced Hypertension” Hypertension. 2005; vol. 45 (Part 2), pp. 759-765.
Koerner, Et Al.: “Polymorphisms in the Human Soluble Epoxide Hydrolase GeneEPHX2Linked to Neuronal Survival After Ischemic Injury” The Journal of Neuroscience. Apr. 25, 2007; vol. 27, No. 17, pp. 4642-4649.
Krotz, Et Al.: “Membrane Potential-Dependent Inhibition of Platelet Adhesion to Endothelial Cells by Epoxyeicosatrienoic Acids” Arterioscler Thrombosis Vascular Biology. 2004; vol. 24, pp. 595-600.
Lee, Et Al.: “Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) and Risk of Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study” Human Molecular Genetics. 2006; vol. 15, No. 10, pp. 1640-1649.
Loch, Et Al.: “Prevention of Hypertension in DOCA-Salt Rats by an Inhibitor of Soluble Epoxide Hydrolase” Cell Biochemistry and Biophysics. 2007; vol. 47, pp. 87-97.
Sato, Et Al.: “Soluble Epoxide Hydrolase Variant (Glu287Arg) Modifies Plasma Total Cholesterol and Triglyceride Phenotype in Familial Hypercholesterolemia: Intrafamilial Association Study in an Eight-Generation Hyerlipidemic Kindred” Journal of Human Genetics. 2004; vol. 49, pp. 29-34.
Sinal, Et Al.: “Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation” The Journal of Biological Chemistry. 2000; vol. 275, No. 51, pp. 40504-40510.
Spector, Et Al.: “Epoxyeicosatrienoic Acids (Eets): Metabolism and Biochemical Function” Progress in Lipid Research. 2004; vol. 43, pp. 55-90.
Wei, Et Al.: “Sequence Variation in the Soluble Epoxide Hydrolase Gene and Subclinical Coronary Atherosclerosis: Interaction With Cigarette Smoking” Atherosclerosis. 2007; vol. 190, pp. 26-34.
Xu, Et Al.: “Prevention and Reversal of Cardiac Hypertrophy by Soluble Epoxide Hydrolase Inhibitors” Proceedings National Academy of Sciences. 2006; vol. 103, No. 49, pp. 18733-18738.
Zhao, Et Al.: “Soluble Epoxide Hydrolase Inhibition Protects the Kidney from Hypertension-Induced Damage” Journal of the American Society of Nephrology, 2004, vol. 15, pp. 1244-1253.

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