Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Treating polymer containing material or treating a solid...
Reexamination Certificate
2010-10-05
2011-12-27
Seidleck, James J (Department: 1765)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Treating polymer containing material or treating a solid...
C528S494000, C528S486000
Reexamination Certificate
active
08084572
ABSTRACT:
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
REFERENCES:
patent: 4670417 (1987-06-01), Iwasaki et al.
patent: 5252714 (1993-10-01), Harris et al.
patent: 5281698 (1994-01-01), Nitecki
patent: 5468478 (1995-11-01), Saifer et al.
patent: 5650234 (1997-07-01), Dolence et al.
patent: 5672662 (1997-09-01), Harris et al.
patent: 5824784 (1998-10-01), Kinstler et al.
patent: 5900461 (1999-05-01), Harris
patent: 5932462 (1999-08-01), Harris et al.
patent: 6046305 (2000-04-01), Choi
patent: 6348558 (2002-02-01), Harris et al.
patent: 6413507 (2002-07-01), Bentley et al.
patent: 6495659 (2002-12-01), Bentley et al.
patent: 6774180 (2004-08-01), Kozlowski et al.
patent: 7053150 (2006-05-01), Kozlowski et al.
patent: 7834138 (2010-11-01), Kozlowski et al.
patent: 2006/0194940 (2006-08-01), Kozlowski
patent: 8-59818 (1996-03-01), None
patent: WO 95/11924 (1995-05-01), None
patent: WO 99/29759 (1999-06-01), None
patent: WO 99/45964 (1999-09-01), None
patent: WO 01/26692 (2001-04-01), None
Abuchowski, et al., “Cancer Therapy with Chemically Modified Enzymes. I. Antitumor Properties of Polyethylene Glycol-Asparaginase Conjugates,” Cancer Biochem. Biophys, 7:175-186 (1984).
Andresz, et al., Makromol. Chem., 179:301-312 (1978).
Beauchamp, et al., “A New Procedure for Synthesis of Polyethylene Glycol-Protein Adducts; Effects on Function, Receptor Recognition, and Clearance of Superoxide Dismutase, Lactoferrin, and α2-Macroglobulin,” Analytical Biochemistry, 131:25-33 (1983).
Brinkley, “A brief survey of methods for preparing protein conjugates with dyes, haptens, and cross-linking reagents,” Bioconjug. Chem, 3:2-13 (1992).
Buckman, et al., “Functionalization of Poly(ethylene glycol) and Monomethoxy-Poly(ethylene glycol),” Makromol. Chem., 182:1379-1384 (1981).
Choi, et al., “Star-Shaped Poly(Ether-Ester) Block Copolymers: Synthesis, Characterization, and Their Physical Properties”, Macromolecules, vol. 31, pp. 8766-8774, (1998).
Duncan, et al., “A new reagent which may be used to introduce sulfhydryl groups into proteins, and its use in the preparation of conjugates for immunoassay”, Anal. Biochem, 132(1):68-73 (1983).
Elling, et al., “Immunoaffinity Partitioning: Synthesis and Use of Polyethylene Glycol-Oxirane for Coupling to Bovine Serum Albumin and Monoclonal Antibodies,” Biotechnology and Applied Biochemistry, 13:354-362 (1991).
Goodson, et al., “Site-Directed PEGylation of Recombinant Interleukin-2 at its Glycosylation Site,” Bio/Technology, 8(4):343-346 (1990).
Greenwald, et al., “Highly Water Soluble Taxol Derivatives: 7-Polyethylene Glycol Carbamates and Carbonates,” J. Org. Chem., 60:331-336 (1995).
Harris, et al., “Synthesis and Characterization of Poly(ethylene glycol) Derivatives,” J. Polym. Sci. Schem. Ed., 22:341-352 (1984).
Ishizu, et al., “Synthesis of Functional Star-Shaped Poly(ethylene Oxide) Using the Macromonomer Technique”, Macromol. Rapid Commun., vol. 21, pp. 979-982, (2000).
Joppich, et al., “Synthesis of Glycyl-L-tryptophylglycine Substituted by Poly(ethylene oxide) at both the Carboxy and the Amino End Groups,” Makromol. Chem., 180:1381-1384 (1979).
Kogan, “The Synthesis of Substituted Methoxy-Poly(ethylene glycol) Derivatives Suitable for Selective Protein Modification,” Synthetic Communications, 22(16):2417-2424 (1992).
Mattson, et al., “A practical approach to crosslinking,” Mol. Biol. Rep. 17(3):167-183 (1993).
Means, et al., “Chemical modifications of proteins: history and applications,” Bioconjug. Chem. 1:2-12 (1990).
Okamoto, et al., “Kinetic Study on Reactions Between Polymer Chain-Ends—II. Reactions Between Chlorosulphonyl-Ended and Primary Amino-Ended Polyoxyethylenes Followed by Fluorometry,” Eur. Polym J., 19(4):341-346 (1983).
Olson, et al., “Preparation and Characterization of Poly(ethylene glycol)ylated Human Growth Hormone Antagonist,” Chemistry and Biological Applications, pp. 170-181 (1997).
Pitha, et al., “Detergents Linked to Polysaccharides” Preparation and Effects on Membranes and Cells, Eur. J. Biochem., 94:11-18 (1979).
Romani, et al., “Synthesis of Unsymmetrical Cystine Peptides: Directed Disulfide Pairing with the Sulfenohydrazide Method,” Chemistry of Peptides and Proteins, 2:29-34 (1984).
Sartore, et al., “Enzyme Modification by MPEG with an Amino Acid or Peptide as Spacer Arms,” Applied Biochemistry and Biotechnology, 27:45-54 (1991).
Sawhney, et al., “Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly(α-hydroxy acid) Diacrylate Macromers,” Macromolecules, 26:581-587 (1993).
Tondelli, et al., “Poly(ethylene Glycol) Imidazolyl Formates as Oligomeric Drug-Binding Matrices,” Journal of Controlled Release, 1:251-257 (1985).
Veronese, et al., “Activation of Monomethoxy-Polyethylene Glycols by Phenylchloroformates and Modification of Ribonuclease and Superoxide Dismutase,” Applied Biochemistry and Biotechnology, 11:141-152 (1985).
Woghiren, et al., “Protected Thiol-Polyethylene Glycol: A New Activated Polymer for Reversible Protein Modification,” Bioconjugate Chem., 4:314-318 (1993).
Wong, et al., “Chemical crosslinking and the stabilization of proteins and enzymes,” Enzyme Microb. Technol. 14:866-874 (1992).
Zalipsky, et al., “Attachment of Drugs to Polyethylene Glycols,” Eur. Polym. J., 19(12):1177-1183 (1983).
Zalipsky, “Chemistry of polyethylene glycol conjugates with biologically active molecules,” Advanced Drug Delivery Reviews, 16:157-182 (1995).
Enzon Pharmaceuticals, Macromolecular Engineering Technologies, pp. 1-14, (2004).
NEKTAR™—Transforming Therapeutics, Nektar Molecule Engineering: Polyethylene Glycol and Derivatives for Advanced PEGylation, pp. 1-20, Catalog—2003, (Jul. 2003).
NEKTAR™—Transforming Therapeutics, Nektar Advanced PEGylation: Polyethylene Glycol and Derivatives for Advanced PEGylation, pp. 1-24, Catalog—2004, (Jul. 2004).
NEKTAR™—Transforming Therapeutics, Nektar Advanced PEGylation: Polyethylene Glycol and Derivatives for Advanced PEGylation, pp. 1-30, (Catalog 2005-2006).
NOF Corporation, “PEG Derivatives, Phospholipid and Drug Delivery Materials for Pharmaceuticals”, pp. 1-46, Catalogue 2003-1st, (Jan. 2003).
NOF Corporation, “PEG Derivatives, Phospholipid and Drug Delivery Materials for Pharmaceuticals”, pp. 1-50, Catalogue 2003-2nd, (Mar. 2004).
NOF Corporation, “PEG Derivatives, Phospholipids and Drug Delivery Materials for Pharmaceutical Products and Formulations”, pp, 1-59, Catalogue Ver. 8, (Apr. 2006).
Polypure, Products; PEG amines; PEG acids and amino acids; PEG thiols and disulfides; BIOTINS, (Apr. 2004).
Polypure, Products; PEG amines; PEG acids and amino acids; PEG thiols and disulfides; BIOTINS, (Apr. 2005).
Quanta Biodesign, Labeling, Derivatization and Crosslinking Reagents for Biological and Related Materials with dPEG™, pp. 1-38, (Mar. 12, 2004).
Quanta Biodesign, Labeling, Modification and Crosslinking Reagents incorporating our unique monodispersed dPEG™ Technology, pp, 1-31, (Nov. 5, 2004).
Quanta Biodesign, Ltd., Leading innovator, producer and provider of monodisperse discrete PEG™ (dPEG™) derivatives, (Product Catalog), pp. 1-51, (Updated: Jul. 18, 2005).
Quanta Biodesign, Ltd., Leading innovator, producer and provider of monodisperse discrete PEG™ (dPEG™)
Bentley Michael D.
Fang Zhihao
Kozlowski Antoni
Sander Tony L.
Shen Xiaoming
Listvoyb Gregory
Marquart Timothy A.
Nektar Therapeutics
Seidleck James J
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