Segmented polymers and their conjugates

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Treating polymer containing material or treating a solid...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C528S494000, C528S486000, C530S815000

Reexamination Certificate

active

07834138

ABSTRACT:
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.

REFERENCES:
patent: 4670417 (1987-06-01), Iwasaki et al.
patent: 5252714 (1993-10-01), Harris et al.
patent: 5281698 (1994-01-01), Nitecki
patent: 5468478 (1995-11-01), Saifer et al.
patent: 5650234 (1997-07-01), Dolence et al.
patent: 5672662 (1997-09-01), Harris et al.
patent: 5824784 (1998-10-01), Kinstler et al.
patent: 5900461 (1999-05-01), Harris
patent: 5932462 (1999-08-01), Harris et al.
patent: 6046305 (2000-04-01), Choi
patent: 6348558 (2002-02-01), Harris et al.
patent: 6495659 (2002-12-01), Bentley et al.
patent: 2006/0194940 (2006-08-01), Kozlowski
patent: 99/45964 (1999-09-01), None
patent: 01/26692 (2001-04-01), None
Abuchowski, et al., “Cancer Therapy with Chemically Modified Enzymes. I. Antitumor Properties of Polyethylene Glycol-Asparaginase Conjugates,”Cancer Biochem. Biophys, 7:175-186 (1984).
Andresz, et al.,Makromol. Chem., 179:301-312 (1978).
Beauchamp et al., “A New Procedure for Synthesis of Polyethylene Glycol-Protein Adducts; Effects on Function, Receptor Recognition, and Clearance of Superoxide Dismutase, Lactoferrin, and α2-Macroglobulin,”Analytical Biochemistry, 131:25-33 (1983).
Brinkley, M., A brief survey of methods for preparing protein conjugates with dyes, haptens, and cross-linking reagents.Bioconjug. Chem, 3:2-13 (1992).
Buckman, et al., “Functionalization of Poly(ethylene glycol) and Monomethoxy-Poly(ethylene glycol),”Makromol. Chem., 182:1379-1384 (1981).
Duncan, et al., A new reagent which may be used to introduce sulfhydryl groups into proteins, and its use in the preparation of conjugates for immunoassay.Anal. Biochem. 132(1):68-73 (1983).
Elling, et al., “Immunoaffinity Partitioning: Synthesis and Use of Polyethylene Glycol-Oxirane for Coupling to Bovine Serum Albumin and Monoclonal Antibodies,”Biotechnology and Applied Biochemistry, 13:354-362 (1991).
Goodson, et al., “Site-Directed PEGylation of Recombinant Interleukin-2 at its Glycosylation Site,”Bio/Technology, 8(4):343-346 (1990).
Greenwald, et al., “Highly Water Soluble Taxol Derivatives: 7-Polyethylene Glycol Carbamates and Carbonates,”J. Org. Chem., 60:331-336 (1995).
Harris, et al., “Synthesis and Characterization of Poly(ethylene glycol) Derivatives,”J. Polym. Sci. Schem. Ed., 22:341-352 (1984).
Joppich et al., “Synthesis of Glycyl-L-tryptophylglycine Substituted by Poly(ethylene oxide) at both the Carboxy and the Amino End Groups,”Makromol. Chem., 180:1381-1384 (1979).
Kogan, “The Synthesis of Substituted Methoxy-Poly(ethylene glycol) Derivatives Suitable for Selective Protein Modification,”Synthetic Communications, 22(16):2417-2424 (1992).
Mattson, G., et al., “A practical approach to crosslinking,”Mol. Biol. Rep. 17(3):167-183 (1993).
Means, G.E., et al., Chemical modifications of proteins: history and applications.Bioconjug. Chem. 1:2-12 (1990).
Okamoto, et al., “Kinetic Study on Reactions Between Polymer Chain-Ends—II. Reactions Between Chlorosulphonyl-Ended and Primary Amino-Ended Polyoxyethylenes Followed by Fluorometry,”Eur. Polym J., 19(4):341-346 (1983).
Olson, et al., “Preparation and Characterization of Poly(ethylene glycol)ylated Human Growth Hormone Antagonist,”Chemistry and Biological Applications, pp. 170-181 (1997).
Pitha, et al., “Detergents Linked to Polysaccharides Preparation and Effects on Membranes and Cells,”Eur. J. Biochem., 94:11-18 (1979).
Romani, et al., “Synthesis of Unsymmetrical Cystine Peptides: Directed Disulfide Pairing with the Sulfenohydrazide Method,”Chemistry of Peptides and Proteins, 2:29-34 (1984).
Sartore, et al., “Enzyme Modification by MPEG with an Amino Acid or Peptide as Spacer Arms,”Applied Biochemistry and Biotechnology, 27:45-54 (1991).
Sawhney, et al., “Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly(α-hydroxy acid) Diacrylate Macromers,”Macromolecules, 26:581-587 (1993).
Tondelli, et al., “Poly(ethylene Glycol) Imidazolyl Formates as Oligomeric Drug-Binding Matrices,”Journal of Controlled Release, 1:251-257 (1985).
Veronese, et al., “Activation of Monomethoxy-Polyethylene Glycols by Phenylchloroformates and Modification of Ribonuclease and Superoxide Dismutase,”Applied Biochemistry and Biotechnology, 11:141-152 (1985).
Woghiren, et al., “Protected Thiol-Polyethylene Glycol: A New Activated Polymer for Reversible Protein Modification,”Bioconjugate Chem., 4:314-318 (1993).
Wong, et al., Chemical crosslinking and the stabilization of proteins and enzymes.Enzyme Microb. Technol. 14:866-874 (1992).
Zalipsky, et al., “Attachment of Drugs to Polyethylene Glycols,”Eur. Polym. J., 19(12):1177-1183 (1983).
Zalipsky, “Chemistry of polyethylene glycol conjugates with biologically active molecules,”Advanced Drug Delivery Reviews, 16:157-182 (1995).
Product description from Shearwater Polymers, Inc., pp. 2-49 (1995).
Catalog of “Polyethylene Glycol Derivatives” from Shearwater Polymers, Inc.; pp. 1-53 (1997-1998).
Catalog of “Polyethylene Glycol and Derivatives” from Shearwater Polymers, Inc.; pp. 1-50 (2000).
Catalog of “Polyethylene Glycol Derivatives for Biomedical Applications” from Shearwater Polymers, Inc.; pp. 1-17 (2001).
Nektar Molecule Engineering Catalog of “Polyethylene Glycol Derivatives for Advanced PEGylation,” pp. 1-21 (2003).
Catalog of “PEG Derivatives, Phospholipid and Drug Delivery Materials for Pharmaceuticals” from NOF Corporation; pp. 1-46 (2003, 1sted).
Catalog of “PEG Derivatives, Phospholipid and Drug Delivery Materials for Pharmaceuticals” from NOF Corporation; pp. 1-46 (2003, 2nded).
Enzon Pharmaceuticals, Macromolecular Engineering Technologies, pp. 1-14; (2004).
Nektar™—Transforming Therapeutics, Nektar Advanced PEGylation: Polyethylene Glycol and Derivatives for Advanced PEGylation, pp. 1-24, (Catalog—2004).
NOF Corporation, “PEG Derivatives, Phospholipids and Drug Delivery Materials for Pharmaceutical Products and Formulations”, pp. 1-59, (Catalogue Ver. 8—Apr. 2006).
Polypure, Products; PEG amines; PEG acids and amino acids; PEG thiols and disulfides; BIOTINS, (Apr. 2004).
Polypure, Products; PEG amines; PEG acids and amino acids; PEG thiols and disulfides; BIOTINS, (Apr. 2005).
Quanta Biodesign, Labeling, Derivatization and Crosslinking Reagents for Biological and Related Materials with dPEG™, pp. 1-38, (Mar. 12, 2004).
Quanta Biodesign, Labeling, Modification and Crosslinking Reagents incorporating our unique monodispersed dPEG™ Technology, pp. 1-31, (Nov. 5, 2004).
Quanta Biodesign, Ltd., Leading innovator, producer and provider of monodisperse discrete PEG™ (dPEG™) derivatives, (Product Catalog), pp. 1-51, (Updated: Jul. 18, 2005).
Quanta Biodesign, Ltd., Leading innovator, producer and provider of monodisperse discrete PEG™ (dPEG™) derivatives, (Product Catalog), pp. 1-51, (Updated: Nov. 17, 2005).
Choi, Y.K. et al., “Star-Shaped Poly(Ether-Ester) Block Copolymers: Synthesis, Characterization, and Their Physical Properties”,Macromolecules, 31:8766-8744 (1998).
Ishizu, K. And Kitano, H., “Synthesis of Functional Star-Shaped Poly (ethylene Oxide) Using the Macromonomer Technique”,Macromol. Rapid Commun., 21:979-982 (2000).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Segmented polymers and their conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Segmented polymers and their conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Segmented polymers and their conjugates will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4150617

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.