Segmented polymers and their conjugates

Details Segmented polymers and their conjugates Segmented polymers and their conjugates

2006-05-30

2006-05-30

Acquah, Samuel A. (Department: 1711)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

C525S054100, C525S398000, C525S399000, C525S400000, C525S437000, C525S535000, C525S539000, C525S540000, C514S002600, C514S023000, C514S04400A, C514S054000, C514S103000, C514S476000, C514S506000, C514S553000, C514S580000

Reexamination Certificate

active

07053150

ABSTRACT:
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.

REFERENCES:
patent: 4670417 (1987-06-01), Iwasaki et al.
patent: 5252714 (1993-10-01), Harris et al.
patent: 5281698 (1994-01-01), Nitecki
patent: 5468478 (1995-11-01), Saifer et al.
patent: 5650234 (1997-07-01), Dolence et al.
patent: 5672662 (1997-09-01), Harris et al.
patent: 5824784 (1998-10-01), Kinstler et al.
patent: 5900461 (1999-05-01), Harris
patent: 5932462 (1999-08-01), Harris et al.
patent: 6348558 (2002-02-01), Harris et al.
patent: WO 99/45964 (1999-09-01), None
patent: WO 01/26692 (2001-04-01), None
Abuchowski et al., “Cancer Therapy with Chemically Modified Enzymes. I. Antitumor Properties of Polyethylene Glycol-Asparaginase Conjugates,”Cancer Biochem. Biophys, 7:175-186 (1984).
Andresz et al.,Makromol. Chem., 179:301-312 (1978).
Beauchamp et al., “A New Procedure for Synthesis of Polyethylene Glycol-Protein Adducts; Effects on Function, Receptor Recognition, and Clearance of Superoxide Dismutase, Lactoferrin, and α2-Macroglobulin,”Analytical Biochemistry, 131:25-33 (1983).
Brinkley, M. A brief survey of methods for preparing protein conjugates with dyes, haptens, and cross-linking reagents.Bioconjug. Chem.3:2-13 (1992).
Buckman et al., “Functionalization of Poly(ethylene glycol) and Monomethoxy-Poly(ethylene glycol),”Makromol. Chem., 182:1379-1384 (1981).
Duncan, R.J., Weston, P.D., Wrigglesworth, R. A new reagent which may be used to introduce sulfhydryl groups into proteins, and its use in the preparation of conjugates for immunoassay.Anal. Biochem.132(1):68-73 (1983).
Elling et al., “Immunoaffinity Partitioning: Synthesis and Use of Polyethylene Glycol-Oxirane for Coupling to Bovine Serum Albumin and Monoclonal Antibodies,”Biotechnology and Applied Biochemistry, 13:354-362 (1991).
Goodson et al., “Site-Directed PEGylation of Recombinant Interleukin-2 at its Glycosylation Site,”Bio/Technology, 8(4):343-346, (1990).
Greenwald et al., “Highly Water Soluble Taxol Derivatives: 7-Polyethylene Glycol Carbamates and Carbonates,”J. Org. Chem., 60:331-336 (1995).
Harris et al., “Synthesis and Characterization of Poly(ethylene glycol) Derivatives,”J. Polym. Sci. Chem. Ed., 22:341-352 (1984).
Joppich et al., “Synthesis of Glycyl-L-tryptophylglycine Substituted by Poly(ethylene oxide) at both the Carboxy and the Amino End Groups,”Makromol. Chem., 180:1381-1384 (1979).
Kogan, “The Synthesis of Substituted Methoxy-Poly(ethylene glycol) Derivatives Suitable for Selective Protein Modification,”Synthetic Communications, 22(16):2417-2424 (1992).
Mattson, G., Conklin, E., Desai, S., Nielander, G., Savage, M.D. and Morgensen, S. A practical approach to crosslinking.Mol. Biol. Rep.17(3):167-183 (1993).
Means, G.E. and Feeney, R.E. Chemical modifications of proteins: history and applications.Bioconjug. Chem.1:2-12 (1990).
Okamoto et al., “Kinetic Study on Reactions Between Polymer Chain-Ends—II. Reactions Between Chlorosulphonyl-Ended and Primary Amino-Ended Polyoxyethylenes Followed by Fluorometry”,Eur. Polym. J., 19(4):341-346 (1983).
Pitha et al., “Detergents Linked to Polysaccharides: Preparation and Effects on Membranes and Cells,”Eur. J. Biochem., 94:11-18 (1979).
Sartore et al., “Enzyme Modification by MPEG with an Amino Acid or Peptide as Spacer Arms,”Applied Biochemisty and Biotechnology, 27:45-54 (1991).
Sawhney et al., “Bioerodible Hydrogels Based on Photopolymerized Poly(ethylen glycol)-co-poly(α-hydroxy acid) Diacrylate Macromers,”Macromolecules, 26:581-587 (1993).
Tondelli et al., “Poly(Ethylene Glycol) Imidazolyl Formates as Oligomeric Drug-Binding Matrices,”Journal of Controlled Release, 1:251-257 (1985).
Veronese et al., “Activation of Monomethoxy-Polyethylene Glycols by Phenylchloroformates and Modification of Ribonuclease and Superoxide Dismutase,”Applied Biochemistry and Biotechnology, 11:141-152 (1985).
Woghiren et al., “Protected Thiol-Polyethylene Glycol: A New Activated Polymer for Reversible Protein Modification,”Bioconjugate Chem., 4:314-318 (1993).
Wong, S.S. and Wong, L.J. Chemical crosslinking and the stabilization of proteins and enzymes.Enzyme Microb. Technol.14:866-874 (1992).
Zalipsky et al., “Attachment of Drugs to Polyethylene Glycols,”Eur. Polym. J., 19(12):1177-1183 (1983).
Zalipsky, “Chemistry of polyethylene glycol conjugates with biologically active molecules”,Advanced Drug Delivery Reviews, 16:157-182 (1995).
Product description from Shearwater Polymers, Inc., pp. 2-49. (1995).
Catalog of “Polyethylene Glycol Derivatives” from Shearwater Polymers, Inc.; pp. 1-53 (1997-1998).
Catalog of “Polyethylene Glycol and Derivatives” from Shearwater Polymers, Inc., pp. 1-50 (2000).
Catalog of “Polyethylene Glycol and Derivatives for Biomedical Applications” from Shearwater Polymers, Inc., pp. 1-17 (2001).
Nektar Molecule Engineering Catalog of “Polyethylene Glycol Derivatives for Advanced PEGylation”, pp. 1-21 (2003).
Catalog of “PEG Derivatives, Phospholipid and Drug Delivery Materials for Pharmaceuticals” from NOF Corporation; pp. 1-46 (2003, 1sted).
Catalog of “PEG Derivatives, Phospholipid and Drug Delivery Materials for Pharmaceuticals” from NOF Corporation; pp. 1-50 (2003, 2nded).

Affiliated with

Also associated with

Rating

Segmented polymers and their conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Segmented polymers and their conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Segmented polymers and their conjugates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3575246