Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system
Patent
1993-08-31
1995-08-22
Green, Randall L.
Surgery
Controlled release therapeutic device or system
Osmotic or diffusion pumped device or system
424473, A61K 922
Patent
active
054434610
ABSTRACT:
Diffusional delivery devices are constructed in two or more compartments, each containing a separate drug or other beneficial agent, and each arranged to permit diffusion of the agent out of the device through an individually-characterized agent-permeable wall segment. The diffusion rates of the various agents relative to one another are set and controlled by the parameters of the individual wall segments, such as the surface area of the wall segment, the average thickness of the wall segment, and the permeability of the wall segment for the particular agent. The permeability may be varied by variations in the chemical composition of the wall segment. Using these parameters rather than blending the agents at calculated ratios in a single formulation for diffusion through a single wall permits a wider range of, and greater flexibility in, variation between the diffusion rates of the different agents. This is of value when the simultaneous administration of agents at a specified ratio is desired.
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Atkinson Linda E.
Dunn John T.
Gale Robert M.
Rivera David L.
ALZA Corporation
Green Randall L.
Ito Richard T.
Mandell Edward L.
Stone Steven F.
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