Securin is required for chromosomal stability in human cells

Details Securin is required for chromosomal stability in human cells Securin is required for chromosomal stability in human cells

2008-04-08

2008-04-08

Canella, Karen A. (Department: 1643)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S375000, C436S063000, C436S064000

Reexamination Certificate

active

09815340

ABSTRACT:
Securin-deficient cells and their isogenic securin-proficient counterparts are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to preferentially inhibit or kill a securin-deficient cell. The association of securin deficiency and chromosomal instability leading to aneuploidy, renders securin an excellent target for chemotherapeutic drug development.

REFERENCES:
patent: WO98/22587 (1998-05-01), None
Morales et al, Oncogene, Jan. 20, 2000, vol. 19, pp. 403-409.
Zur et al, EMBO, Feb. 15, 2000, vol. 20, pp. 792-801.
Lengauer et al, Nature, 1998, vol. 396, pp. 643-649.
Andrew Bush et al, “c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets”, Genes & Development, vol. 12, 1998, pp. 3797-3802.
Hitoshi Matsushime et al, “Identification and Properties of an Atypical Catalytic Subunit (p34PSK-J3/cdk4) for Mammalian D Type G1 Cyclins”, Cell, vol. 71, 1992, pp. 323-334.
Martins Eilers et al, “The MYC protein activates transcription of the α-prothymosin gene”, The EMBO Journal, vol. 10, No. 1, 1991, pp. 133-141.
Mark E. Ewen et al, “TGFβ Inhibition of Cdk4 Synthesis Is Linked to Cell Cycle Arrest”, Cell, vol. 74, 1993, pp. 1009-1020.
Heiko Hermeking et al, “Abrogation of p53-induced cell cycle arrest by c-Myc: evidence for an inhibitor of p21”, Oncogene, vol. 11, 1995, pp. 1409-1415.
Kathryn M. Latham et al, “Inhibition of p53-Mediated Growth Arrest by Overexpression of Cyclin-Dependent Kinases”, Molecular and Cellular Biology, vol. 16, No. 8, 1996, pp. 4445-4455.
Jim Wang et al, “Myc activates telomerase”, Genes & Development, vol. 12, 1998, pp. 1769-1774.
Abdel G. Elkahloun et al, “Transcrpit Mapping in a 46-kb Sequenced Region at the Core of 12q13.3 Amplification in Human Cancers”, Genomics, vol. 42, 1997, pp. 295-301.
Maria K. Mateyak et al, “Phenotypes of c-Myc-deficient Rat Fibroblasts Isolated by Targeted Homologous Recombination”, Cell Growth & Differentiation, vol. 8, 1997, pp. 1039-1048.
Philipp Steiner et al, “Identification of a Myc-dependent step during the formation of active G1cyclin-cdk complexes”, The EMBO Journal, vol. 14, No. 19, 1995, pp. 4814-4826.
Eric C. Holland et al, “Modeing mutations in the G1arrest pathway in human gliomas: oxerexpression of CDK4 but not loss of IND4aARF induces hyperploidy in cultured mouse astrocytes”, Genes & Development, vol. 12, 1998, pp. 3644-3649.
Maria K. Mateyak et al, c-Myc Regulates Cyclin D-Cdk4 and -Cdk6 Activity but Affects Cell Cycle Progression at Multiple Independent Points, Molecular and Cellular Biology, vol. 19, No. 7, 1999, pp. 4672-4683.
Jaromir Vlach et al, “Growth arrest by the cyclin-dependent kinase inhibitor p27 KIP1 is abrogated by c-Myc”, The EMBO Journal, vol. 15, No. 23, 1996, pp. 6595-6604.

Affiliated with

Also associated with

Rating

Securin is required for chromosomal stability in human cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Securin is required for chromosomal stability in human cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Securin is required for chromosomal stability in human cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3904252