Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2005-08-23
2005-08-23
Ulm, John (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S069100, C435S069700, C536S023400
Reexamination Certificate
active
06933364
ABSTRACT:
A recombinant soluble human thyroid hormone receptor, comprising an extracellular domain moiety of a human thyroid hormone receptor, or a mutant thereof, being secretory, and having reactivity with an anti-human thyroid stimulating hormone receptor autoantibody; a composition for assaying an anti-human thyroid stimulating hormone receptor antibody, comprising the receptor and a carrier or diluent; a method for assaying an anti-human thyroid stimulating hormone receptor antibody, comprising reacting an anti-human thyroid stimulating hormone receptor antibody with the receptor; and a process for producing a recombinant soluble human thyroid hormone receptor which is secretory and has reactivity with an anti-human thyroid stimulating hormone receptor autoantibody, comprising infecting an insect cell with a recombinantbaculovirusintroduced with an extracellular domain moiety of a gene encoding a human thyroid hormone receptor or a mutant thereof, and culturing the infected cell.
REFERENCES:
patent: 5144007 (1992-09-01), Pfahl
patent: 5438126 (1995-08-01), DeGroot et al.
patent: 5925549 (1999-07-01), Hsueh et al.
Rapoport, B., et al. (1998) “The Thyrotropin (TSH) Receptor: Interaction with TSH and Autoantibodies” Endocrine Reviews, 19;(6): 673-716.
Kosugi, S., et al. (1997) “Epitope Analysis of the Thyrotropin Receptor” Molecular and Cellular Endocrinology, 128: 11-18.
Dallas, J., et al. (1996) “Thyrotropin (TSH) Receptor Antibodies (TSHrAb) Can Inhibit TSH-Mediated Cyclic Adenosine 3′, 5′-Monophosphate Production in Thyroid Cells by Either Blocking TSH Binding or Affecting a Step Subsequent to TSH Binding” Endocrinology, 137(8): 3329-3339.
Seetharamaiah et al, Journal of Immunology, vol. 158, “Require- of Glycosylation of the Human . . . ”, pp. 2798-2804, 1997.
Park et al, Molecular and Cellular Endocrinology, vol. 147, “Different bioactivities of human . . . ”, pp. 133-142, 1999.
Patibandla et la, ENDOCRINOLOGY, vol. 138, No. 4, “Differential Reactivities of Recombinant . . . ”, pp. 1559-1566, 1997.
Chazenbalk et al, Journal of Biological Chemistry, vol. 272, No. 30, “Engineering the Human . . . ”, pp. 18959-18965, Jul. 25, 1997.
Seetharamaiah et al, AUTOIMMUNITY, vol. 14, “Induction of TSH Binding Inhibitory Immunoglobulins . . . ”, pp. 315-320, 1993.
Vlase et al, ENDOCRINOLOGY, vol. 138, No. 4, “Folding-Dependent Binding of Thyrotropin (TSH) . . . ”, pp. 1658-1666, 1997.
Huang et al, Journal of Molecular Endoctrinology, vol. 10, “The thyrotrophin hormone receptor of Graves . . . ”, pp. 127-142, 1993.
Smith et al, Endocrine Reviews, vol. 9, No. 1, “Autoantibodies to the Thyrotropin Receptor”, pp. 106-121, 1988.
Chazenbalk et al, Journal of Biological Chemistry, vol. 270, No. 4, “Expression of the Extracellular . . . ”, pp. 1543-1549, 1994.
Akamizu Takashi
Hattori Yoshiyuki
Jacobson & Holman PLLC
Tosoh Corporation
Ulm John
LandOfFree
Secretory thyroid stimulating hormone receptor, and method... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Secretory thyroid stimulating hormone receptor, and method..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Secretory thyroid stimulating hormone receptor, and method... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3471886