Secretion of insulin-like growth factor-I in E. coli

Details Secretion of insulin-like growth factor-I in E. coli Secretion of insulin-like growth factor-I in E. coli

1991-05-23

1999-09-28

Stanton, Brian R.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435243, 4353201, 435471, 536 231, 536 232, 536 2351, C12N 120, C12N 1511, C12N 1518

Patent

active

059587547

ABSTRACT:
A method for bacterially producing IGF-I is disclosed in which Gram-negative bacteria are caused to express a gene consisting of a lamB or ompF signal sequence operatively joined to a DNA sequence encoding IGF-I and producing IGF-I which is secreted into the periplasmic space of the bacteria.

REFERENCES:
patent: 4738921 (1988-04-01), Belagaje et al.
patent: 5015573 (1991-05-01), Yarranton et al.
Wong et al 1988 Gene 68:193-203.
Sjostrum et al 1987 (Mar.) EMBOJ 6:823-831.
Hoffman et al 1985 Proc Natl Acad Sci USA 82:5107-5111.
Nilsson et al 1985 Nucleic Acids Res. 13:1151-1162.
Dunn et al 1983 J Mol Biol 166:477-535.

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