Secretion of hirudin derivatives

Details Secretion of hirudin derivatives Secretion of hirudin derivatives

1992-11-25

1999-07-06

Ketter, James

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

A61K 3858

Patent

active

059198958

ABSTRACT:
A process for obtaining hirudin derivatives from E. coli secretor mutants which entails:

REFERENCES:
patent: 4457866 (1984-07-01), Karges et al.
patent: 4668662 (1987-05-01), Tripier
patent: 5180668 (1993-01-01), Crause et al.
FEBS Letters, Bd. 202, Nr. 2, Jun. 1986, pp. 373-377; J. Dodt et al.: "Expression, secretion and processing of hirudin in E. coli using the alkaline phosphatase signal sequence".
Applied Microbiology and Biotechnology, Bd. 34, No. 2, Nov. 1990, pp. 203-207, Springer-Verlag; E. Bender et al.: "Synthesis and secretion of hirudin by Streptomyces lividans".
J.C. Janson Trends in Biotechnology vol. 2, No. 2, 1984. "Large Scale Affinity Purificaton-State of the Art and Future Prospects", pp. 31-38.
"Hirudin: A Family of Iso-Proteins Isolation and Sequence Determination of New Hirudins," ISSN 0323-4347, Folia Haematol, Leipzig 115 (1988) 1-2, S. 30-35.
"Primary Structures of New `Iso-hirudins`," FEBS Letters, vol. 225, No. 1, pp. 105-110 (1989).
J.C. Janson Trends in Biotechnology vol. 2 (2) 1984. "Large Scale Affinity Purification" pp. 31-38.

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