Secretion of correctly processed human growth hormone in E. coli

Details Secretion of correctly processed human growth hormone in E. coli Secretion of correctly processed human growth hormone in E. coli

1983-04-25

1988-07-05

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

4351723, 935 13, C12P 2102, C12N 1500

Patent

active

047554657

ABSTRACT:
The production of mature hGH In E. coli and Pseudomonas strains transformed by a plasmid which encodes pre hGH (comprising the signal polypeptide and the hormone itself) is described. These prokaryotes process the pre-hGH to cleave the signal sequence and, thereby, produce mature hGH.

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