Secreted protein factor and cell membrane-bound splice variant

Details Secreted protein factor and cell membrane-bound splice variant Secreted protein factor and cell membrane-bound splice variant

2003-12-31

2008-11-18

Saoud, Christine J. (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C514S002600, C514S012200, C536S023500, C435S069100

Reexamination Certificate

active

07452968

ABSTRACT:
A novel mammalian protein system is disclosed. This system comprises a secreted protein factor and its related membrane-bound splice variant. These novel proteins have no homology to any known protein or class or protein, yet are ubiquitously expressed in nearly all tissue types. Also disclosed are novel nucleic acids that encode the novel polypeptides of the invention. The protein system was discovered in purified populations of murine hematopoieitc stem cells. The cDNAs of the invention were cloned from a marine hematopoietic lineage negative (Lin) library.

REFERENCES:
patent: 2003/0073129 (2003-04-01), Baker et al.
Wells, J.A. (1990). Additivity of mutational effects in proteins. Biochemistry. 29(37):8509-8517.
Ngo et al. (1994). Computational complexity, protein structure prediction, and the Levinthal paradox. In Merz and Le Grand (Eds.) The Protein Folding Problem and Tertiary Structure Prediction. Birkhauser:Boston, pp. 491-495.

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