Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-07
2000-05-30
Kemmerer, Elizabeth
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
435 691, 4352523, 43525411, 536 235, 530350, 530395, 4241851, 4242771, A61K 3818, C07K 1446
Patent
active
060691271
ABSTRACT:
A purified glycoprotein complex of over 1200 kD apparent native molecular weight having a sedimentation value of approtely 25S and having the ability to selectively bind human Mac-2 or interfere with PHA activation of lymphocytes, DNA sequences that encode the protein, and expression systems for expressing it, thus providing for medicaments that are useful for treating or diagnosing diseases, including cancer, infectious disease, and diseases of the immune system.
REFERENCES:
patent: 5298391 (1994-03-01), Iacobelli
patent: 5492899 (1996-02-01), Masor et al.
Aruffo A; Melnick M B Linsley P S; Seed B. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. Journal of Experimental Medicine, (Oct. 1, 1991) 174 (4) 949-52.
Linsley P S; Horn D; Marquardt H; Brown J P; Hellstrom I; Hellstrom K E; Ochs V; Tolention E. Identification of a novel protein secreted by lung carcinoma cells. Biochemistry, (May 20, 1986) 25 (10) 2978-86.
Newburg et al. A human milf factor inhibits binding a human immunodefficeincy virus to the CD4 receptor. Pediatric Research 31:22-28, 1992.
Inohara et al. Interactions between galetin-3 and Mac-2-binding protein mediate cell-cell adhesion. Cancer Research, (Oct. 1, 1996), 56(19):4530-4.
Nonaka et al. Detailed characteristic of a high-molecular weight glycoprotein secreted by lung cancer cells. Japanese Journal of Cancer Research, (Sep. 1993), 84(9):982-8.
Rosenberg I.; Cherayil B.J.; Isselbacher K.J.; Pillai S. Mac-2-binding glycoproteins: Putative ligands for a cytosolic .beta.-galactoside lectin. J. Biol. Chem., (1991) 266/28 (18731-18736, Oct. 1991.
Koths et al. Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain. J. Biol. Chem., (Jul. 5, 1993) 268 (19) 45245-9.
Bowie et al. Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science, (Mar. 16, 1990) 247 (4948) 1306-10.
Casipit Clayton L.
Halenbeck Robert F.
Koths Kirston E.
Taylor Eric W.
Wang Alice M.
Blackburn Robert P.
Chiron Corporation
Kemmerer Elizabeth
Morley Kimberlin L.
Romeo David S.
LandOfFree
Secreted mac-2-binding glycoprotein does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Secreted mac-2-binding glycoprotein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Secreted mac-2-binding glycoprotein will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1910469