Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-05-29
2007-05-29
Nickol, Gary B. (Department: 1646)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S069700, C435S235100, C435S325000, C435S320100, C435S170000, C435S252300, C435S455000, C530S350000
Reexamination Certificate
active
10425586
ABSTRACT:
The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
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Cumberledge Susan
Reichsman Frieda
Rubin Jeffrey S.
Üren Aykut
Basi Nirmal S.
Klarquist & Sparkman, LLP
Nickol Gary B.
The United States of America as represented by the Secretary of
The University of Massachusetts
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