Secreted and transmembrane polypeptides and nucleic acids...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S387100, C530S399000, C536S023100

Reexamination Certificate

active

07151160

ABSTRACT:
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

REFERENCES:
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patent: 6284485 (2001-09-01), Boyle et al.
patent: WO 99 43802 (1998-09-01), None
patent: WO 98 39446 (1999-09-01), None
patent: WO 99/43802 (1999-09-01), None
Wells, J.A. Additivity of Mutational Effects in Proteins. Biochemistry 29:8509-8517 (1990).
Blast Results A1-A23, GenBank, considered do not print.
Blast Results, B1-B6, Dayhoff, considered do not print.
Fijiwara et al., “Human fetal brain cDNA 5′-end GEN-427F07” XP002194032 Database EMBL Online Entry HS427F07B, Feb. 1996.
Hillier et al., “zx05e11.r1 Soares total fetus Nb2HF8 9w . . . ” XP002194033 Database EMBL Online Entry HS1249343, Jun. 1997.
Hideaki et al., “Chicken oocyte growth is mediated by an eight ligand binding repeat . . . ” EMBO Journal, 1995, p. 5165-5175.
Barber et al., “The Receptor for Yolk Lipoprotein Deposition in the Chicken Oocyte,”The Journal of Biological Chemistry266(28): 18761-18770 (1991).
Huang et al., “NMR Solution Structure of Complement-like Repeat CR8 from the Low Density Lipoprotein Receptor-related Protein,”The Journal of Biological Chemistry274(20): 14130-14136 (1999).
42 human EST's putatively encoding proteins having similarity with lipoprotein receptors disclosed before Sep. 17, 1997; Host: NCBI, Database: Genbank.
500 human EST's putatively encoding secreted or transmembrante proteins disclosed before Oct. 28, 1997; Host; NCBI, Database: Genbank.
Lestraval and Fruchart, “Lipoprotein Receptors”, Cell. Mol. Biol., vol. 40, No. 4, pp. 461-481, 1994.

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