Secreted and transmembrane polypeptides and nucleic acids...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S252330, C435S254200, C435S320100, C435S325000, C435S358000, C536S023500, C530S350000

Reexamination Certificate

active

07094567

ABSTRACT:
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

REFERENCES:
patent: WO 99/58660 (1999-11-01), None
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Ashkenazi et al; “Sixty one nuleic acids encoding PRO polypeptides which are useful in the treatment of skin diseases, cancers and neurodegenerative diseases”, P—AAF72391; WO200104311-A1, Feb. 22, 2000; Pub Date Jan. 18, 2001.
Botstein et al; “New antibody that binds to a PRO polypeptide, useful for diagnosing and treating cancers”, P—AAF60352; WO200105836-A1, Dec. 20, 1999; Pub Date Jan. 25, 2001.
Goddard et al; “New isolated antibodies which bind specific polypeptides used for diagnosis and treatment of neoplastic cell growth and proliferation”; P—AAA30032; WO200015666-A2, Sep. 8, 1999; Pub Date Mar. 23, 2000.
Ashkenazi et al; “Nucleic acids encoding PRO polypeptides useful for preventing, diagnosing and treating diagnosing a cardiovascular, endothelial or angiogenic disorders in mammals”, P—AAA77541; WO200032221-A2, Nov. 30, 1999; Pub Date Jun. 8, 2000.
Botstein et al; “Antibodies against specific proteins overexpressed in tumours”, P—AAX28431; WO9914327-A2, Sep. 10, 1998; Pub Date Mar. 25, 1999.
Chen, et al; “New isolated human genes and polypeptides used in, e.g. treatment of gastrointestinal ulceration”, P—AAX52233; WO9914328-A2, Sep. 16, 1998; Pub Date Mar. 25, 1999.
Botstein et al; “Polypeptidic ccompositions and methods for the treatment of tumors”, AX076899; WO 0105836-A 11, Jan. 25, 2001.
Pan, Y and Leiby, K.R.; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseases of the lung, liver, kidney or pancreas”, P—AAC84379; WO200069885-A2, May 15, 2000; Pub Date Nov. 23, 2000.
Bandman et al; “Isolated polynucleotide encoding extracellular matrix or adhesion-associated protein (EXMAD) useful for diagnosing, treating, or preventing disorders associated with expression of EXMAD such as proliferative, immune and genetic disorders”, P—AAC66895; WO200068380-A2, May 10, 2000; Pub Date Nov. 16, 2000.
Pan, Y and Leiby, K.R.; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseases of the lung, liver, kidney or pancreas”, P—AAC84403; WO200069885-A2, May 15, 2000; Pub Date Nov. 23, 2000.
Pan, Y and Leiby, K.R.; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseases of the lung, liver, kidney or pancreas”, P—AAC84401; WO200069885-A2, May 15, 2000; Pub Date Nov. 23, 2000.
Bandman et al; “Extracellular matrix and adhesion-associated proteins”, AX047345; WO 0068380-A 31, Nov. 16, 2000.
Rupp et al; “Identification, genomic organization and mRNA expression of CRELDI, the founding member of a unique family of matricellular proteins”, NM—015513; Gene 293 (1-2), 47-57 (2002).
Wiemann et al; “Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs”, HSM800381; Genome Res. 11(3), 422-435 (2001).
Bandman et al; “Isolated polynucleotide encoding extracellular matris or adhesion-associated protein (EXMAD) useful for diagnosing, treating, or preventing disorders associated with expression of EXMAD such as proliferative, immune and genetic disorders”, P—AAB27228; WO200068380-A2, May 10, 2000; Pub Date Nov. 16, 2000.
Ashkenzai et al; Sixty one nucleic acids encoding PRO polypeptides which are useful in the treatment of skin diseases, cancers and neurodegenerative diseases, P—AAB80230; WO200104311-A1, Feb. 22, 2000; Pub Date Jan. 18, 2001.
Botstein, et al; “New antibody that binds to a PRO polypeptide, useful for diagnosing and treating cancers”, P—AAB68594; WO200105836-A1, Dec. 20, 1999; Pub Date Jan. 25, 2001.
Goddard et al; “New isolated antibodies which bind to specific polypeptides used for diagnosis and treatment of neoplastic cell growth and proliferation”, P—AAY88569; WO200015666-A2, Sep. 8, 1999; Pub Date Mar. 23, 2000.
Ashkenzai et al; “Nucleic acids encoding PRO polypeptides useful for preventing, diagnosing and treating diagnosing a cardiovascular, endothelial or angiogenic disorders in mammals”, P—AAB24396; WO200032221-A2, Nov. 30, 1999; Pub Date Jun. 8, 2000.
Botstein et al; “Antibodies against specific proteins overexpressed in tumours”, P—AAY05281; WO9914327-A2, Sep. 10, 1998; Pub Date Mar. 25, 1999.
Chen et al; “New isolated human genes and polypeptides used in, e.g. treatment of gastrointestinal ulceration”, P—AAY13362; WO9914328-A2, Sep. 16, 1998; Pub Date Mar. 25, 1999.
Pan and Leiby; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseases of the lung, liver, kidney or pancreas”, P—AAB48106; WO200069885-A2, May 15, 2000; Pub Date Nov. 23, 2000.
Pan and Leiby; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseases of the lung, liver, kidney or pancreas”, P—AAB48135; WO200069885-A2, May 15, 2000; Pub Date Nov. 23, 2000.
Pan and Leiby; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseases of the lung, liver, kidney or pancreas”, P—AAB48134; WO200069885-A2, May 15, 2000; Pub Date Nov. 23, 2000.
Pan and Leiby; “Novel nucleic acids encoding secreted or transmembrane proteins, useful for treating, e.g. cancer, hemophilia, anemia, ischemia or diseases of the lung, liver, kidney or pancreas”, P—AAB48133; WO200069885-A2, May 15, 2000; Pub Date Nov. 23, 2000.
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