Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-02-08
2005-02-08
Nickol, Gary B. (Department: 1642)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S320100, C435S325000, C435S069100, C536S023100, C530S350000
Reexamination Certificate
active
06852848
ABSTRACT:
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
REFERENCES:
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Ashkenazi, et al., “New PRO polypeptides and nucleic acid molecules, useful in diagnosing or treating inflammatory diseases, organ failure, atherosclerosis, cardiac injury, infertility, cancer, aids, alzheimer's disease or Parkinson's disease”, P_ACA54834; Patent: US2003017463:A1; filed Jul. 11, 2001.
Ashkenazi, et al., “New PRO polypeptides and nucleic acid molecules, useful in diagnosing or treating inflammatory diseases, organ failure, atherosclerosis, cardiac injury, infertility, cancer, aids, alzheimer's disease or Parkinson's disease”, P_ABX71474; Patent: US2002132240-A1; filed Jul. 18, 2001.
Ashkenazi, et al., “New secreted and transmembrane PRO polypeptides (e.g., PRO533 or PRO245) and genes encoding them, useful for detecting or treating e.g. hyperplasia, endometriosis, cancers, ischemia, coronary arterial disease or inflammation”, P_ABX96043; Patent: US2002160374-A1; filed Jul. 12, 2001.
Baker, et al., “Novel isolated PRO polypeptides e.g., PRO826, PRO1068, PRO1184; PRO1346 and PRO1375, which stimulate proliferation of stimulated T-lymphocytes are therapeutically useful for enhancing immune response and in cancer treatments”, P13ABX89287; Patent: US2003017563-A1; filed May 7, 2002.
Ashkenazi, et al., “Sixty-one isolated nucleic acids encoding a PRO Polypeptide, e.g., PRO245 or PRO1868, useful in chromosome and gene mapping, in generating antisense RNA and DNA, and in treating cancer and alzheimer's disease”, P_ACA05364; Patent: US2003023054-A1; filed Jul. 16, 2001.
Baker, et al., “New secreted and transmembrane nucleic acids and polypeptides, designated as PRO, useful for treating inflammation, organ failure, atherosclerosis, cardiac injury, infertility, birth defects, premature aging, AIDS or cancer”, P_ACA04170; Patent: US2003032155-A1; filed May 3, 2002.
Baker, et al., “New secreted and transmembrane PRO nucleic acids, useful for gene therapy, in chromosome and gene mapping, as chromosome markers, in tissue typing, and in chromosome identification”, P_ACA03749; Patent: US2003036180-A1; field May 9, 2002.
Ashkenazi, et al., “New transmembrane polypeptides and nucleic acids encoding the polypeptides, useful for gene therapy, in chromosome identification, as chromosomes markers, in generating probes and in tissue typing”, P_ACA60026; Patent: US2003003530-A1; filed Jul. 11, 2001.
Ashkenazi, et al., “New isolated nucleic acid encoding a PRO polypeptide, e.g., PRO245 or PRO1868, useful in molecular biology, chromosome and gene mapping, in generating antisense RNA and DNA, and in gene therapy”, P_ACA58319; Patent: US2002192659-A1; filed Jul. 10, 2001.
Baker, et al., “Isolated, secretory and transmembrane PRO polypeptides used to detect other PRO polypeptides, link bioactive molecules to cells expressing PRO polypeptides, and detect the presence of mammalian tumors e.g., lung, breast, prostate, cervical”, P_AAS21390; Paten: WO200140466-A2; filed Dec. 1, 2000.
Ashkenazi, et al., “Isolated nucleic acid useful for e.g., treating pathological disorders encodes a secreted or transmembrane protein”, P_ACA58922; Patent: US2002146709-A1; filed Jul. 18, 2001.
Baker, et al., “New isolated PRO polypeptide useful for treating diabetes, rheumatoid arthritis, sports injuries, obesity, hearing loss in mammals, stroke, or heart attack”, P_ACA67140; Patent: US2003004311; filed Dec. 19, 2001.
Ashkenazi, et al., “Novel composition to inhibit neoplastic cell growth or for treating tumor in mammal comprises polypeptides PRO179, PRO207, PRO320, PRO219, PRO221, PRO224, PRO328, PRO301, PRO526, PRO362, PRO356, PRO509, or PRO866”, P_AAA49719; Patent: WO200037638-A2; filed Dec. 2, 1999.
Chen, et al., “New isolated human genes and polypeptides used in e.g., treatment of gastrointestinal ulceration”, P_AAX52220; Patent: WO9914328-A2; filed Sep. 16, 1998; published Mar. 25, 1999.
Ashkenazi, et al., “New genes and secreted and transmembrane polypeptides (e.g., PRO245 or PRO335), useful for treating or diagnosing e.g., Alzheimer's disease, cancers, hemorrhage, rheumatoid arthritis, diabetes, cirrhosis, ischemia or strokes”, P_ACD07426; Patent: US2002197671-A1; filed Jul. 17, 2001.
Ashkenazi, et al., “Novel secreted and transmembrane polypeptides and polynucleotides encoding them useful for treating abnormal bleeding involved in gynecological disease, skin diseases and neurodegenerative diseases”, P_ACD19669; Patent: US2003027143-A1; filed Jul. 16, 2001.
Baker, et al., “New isolated nucleic acid encoding a PRO polypeptide, e.g. PRO1114 or PRO4978, useful in molecular biology, chromosome and gene mapping, in generating antisense RNA and DNA, and in gene therapy”, P_ACD41941; Patent: US2003036179-A1; filed May 10, 2002.
Baker, et al., “New secreted and transmembrane PRO nucleic acids, for treating inflammation, organ failure, atherosclerosis, cardiac injury, infertility, birth defects, premature aging, acquired immunodeficiency syndrome (AIDS), or cancer”, P_ACD23999; Patent: US2003032156-A1; filed May 6, 2002.
Ashkenazi, et al., “Novel secreted and transmembrane polypeptide for modulating biological activity of cell expressing the polypeptide, identifying agonists or antagonists or polypeptides, and as molecule weight markers”, P_ACD23517; Patent: US2003064923-A1; filed Jul. 13, 2001.
Ashkenazi, et al., “Sixty one nucleic acids encoding PRO polypeptides which are useful in the treatment of skin diseases (e.g. psoriasis), cancers (e.g. lung squamos cell carcinoma) and neurodegenerative diseases e.g. Alzheimer's disease”, P_AAF72378; Patent: WO200104311-A1; filed Feb. 22, 2000; published Jan. 18, 2001.
Ashkenazi, et al., “New isolated nucleic acid for producing a PRO polypeptide, analyzing genetic disorders and treating cardiovascular, endothelial or angiogenic disorders, such as atherosclerosis, wounds or cancer”, P_AAC97417; Patent: WO200053753-A2; filed Jan. 5, 2000.
Ashkenazi, et al., “Novel secreted and transmembrane polypeptide for modulating biological activity of cell expressing the polypeptide, identifying agonists or antagonists or polypeptide, and as molecule weight markers”, P_ACD20031; Patent: US2003036060-A1; filed Jul. 12, 2001.
Ashkenazi, et al., “Novel isolated PRO polypeptides e.g. PRO245 and PRO1868, useful for treating e.g. Parkinson's disease, Alzheimer's discase, amyotrophic lateral sclerosis, cancer, neuropathies, diabetes and psoriasis”, P_ACD23155; Patent: US2003064367-A1; filed Jul. 13, 2001.
Wood, et al., “Secreted and transmembrane polypeptides and nucleic acids encoding the same”, BDI72254; Patent: JP2002223786-A 27; filed Aug. 13, 2002.
Clark, et al., “The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment” AY358895; Genome Res. 13 (10), pp. 2265-2270, 200
Goddard Audrey
Gurney Austin L.
Wood William I.
Barnes Elizabeth M.
Dreger Ginger R.
Genentech Inc.
Heller Ehrman White & McAuliffe LLP
Nickol Gary B.
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