Secreted and transmembrane polypeptides and nucleic acids...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S002600, C530S399000

Reexamination Certificate

active

10243388

ABSTRACT:
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

REFERENCES:
patent: 5536637 (1996-07-01), Jacobs
Huh et al. (2003). Journal of Proteome Research. 2: 405-412.
Haynes et al. (1998). Electrophoresis. 19. 1862-1871.
Ngo et al. Computational complexity, protein structure predidion, and the Levinthal paradox. The Protein Folding Problem andTertiary Structure Prediction, pp. 492-495, 1994.
Wells. J.A. Additivity of mutational effects in proteins. Biochemistry 29 (37): 8509-8517, 1990.
Bork, A. Powers and pitfalls in sequence analysis: the 70% hurdle. Genome Res 102 398-400, 2000.
Skolnick et al. From genes to protein structure and function: novel applications of computational approaches in the genomicera. Trends in Biotech 18(1): 34-39, 2000.
Doerks et al. Protein annotation'. detective work for function prediction. Trends in Genetics 14(6): 248-250, 1998.
Smith et al. The challenges of genome sequence annotation or “The devil is in the details”. Nature Biotech 15: 1222-1223,1997.
Qi et al. (2003). Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells. PNAS, 100, 3305-3310.
Saito-Hisaminato (2002). Genome-wide profiling of gene expression in 29 normal human tissues with a cDNA microarray. DNA research, 9, 35-45.
Bork et al. Go hunting in sequence databases but watch out for the traps. Trends in Genetics. 12410): 425-427, 1996.
Brenner, S.E. Errors in genome function. Trends in Genetics 15(4): 132-133, 1999.
Srausberget al. (2002). Accession No. Q8R2Y3.
Anderson et al (1997). Electrophoresis. 18, 533-537.
Bustin et al (2002). Trends in Mol. Med. 8, 269-272.
Modrek et al (2002). Nature Genetics. 30, 13-19.
Coulson et al (2000). Cancer Res. 60, 1840-1844.
Nagaraja et al. (2006). Oncogene. 25, 2328-2337.
Sagynaliev et al (2005). Proteomics. 5, 3066-3078.
Waghray et al. (2001). Proteomics. 1, 1327-1338.
Chen et al. (2002). Molecular and Cellular Proteomics. 304-313.
Klein et al., “Selection for genes encoding secreted proteins and receptors”Proc. Nat. Acad. Sci. USA93:7108-7113 (1996).
Abe, N., et al., “An Increased High-Mobility Group A2 Expression Level is Associated with malignant Phenotype in Pancreatic Exocrine Tissue,”Br J Cancer—89(11):2104-9 (2003) Abstract.
Ando, M., et al., “Selective Apoptosis of Natural Killer-Cell Tumours by I-Asparaginase,”Br J Haematol.,—130(6):860-8 (2005) Abstract.
Aust, G., et al., “Human Thyroid Carcinoma Cell Lines and Normal Thyrocytes: Expression and Regulation of Matrix Metalloproteinase Inhibitor-1 Messenger-RNA and Protein,”Thyroid—7(5):713-24 (1997) Abstract.
Barnes, V.L., et al., “Expression of Embryonic Fibronectin Isoform EIIIA Parallels Alpha-Smooth Muscle Actin in Maturing and Diseased Kidney,”J Histochem Cytochem.—47(6):787-98 (1999) Abstract.
Bea, S., et al., “BMI-1 Gene Amplification and Overexpression in Hematological Malignancies Occur Mainly in Mantle Cell Lymphonas,”Cancer Res.—61(6):2409-12 (2001) Abstract.
Blaschke, V., et al., “Rapid Quantitation of Proinflammatory and Chemoattractant Cytokine Expression in Small Tissue Samples and Monocyte-Derived Dendritic Cells: Validation of a New Real-Time RT-PCR Technology,”J Immunol Methods.—246(1-2):79-90 (2000) Abstract.
Buckley, A.R., et al., “Butyrate-Induced Reversal of Dexamethasone Resistance in Autonomouse Rat Nb2 Lymphoma Cells,”Apoptosis.—2(6):518-28 (1997) Abstract.
Caberlotto, L. et al.,“Alterations in Neuropeptide Y Levels and Y1 Binding Sites in the Flinders Sensitives Line Rats, A Genetic Animal Model of Depression,”Neurosci Lett.—265(3):191-4 (1999) Abstract.
Caberlotto, L., et al., “Neurokinin 1 Receptor and Relative Abundance of the Short and Long Isoforms in the Human Brain,”Eur J Neurosci.—17(9):1736-46 (2003) Abstract.
Choi, D., et al., “Characterization of Cyclin D2 Expression in Human Endometrium,”J Soc Gynecol Investig.—9(1):41-6 (2002) Abstract.
Couvelard, A., et al., “Human Chorionic Gonadotrophin Beta Expression in Malignant Barrett's Oesophagus,”Virchows Arch.—445(3):279-84 (2004) Abstract.
Dagenais, A., et al., “Downregulation of EnaC Activity and Expression by TNF-Alpha in Alveolar Epithelial Cells,”Am J. Physio Lung Cell Mol Physiol.—286(2):L301-11 (2004) Abstract.
De Boer, C.J., et al., “Involement of the CCNDI Gene in Hairy Cell Leukemia,”Ann Oncol.—7(3):251-6 (1996) Abstract.
Debieve, F., et al., “Inhibin and Activin Production and Subunit Expression in Human Placental Cells Cultured in Vitro,”Mol Hum Reprod.—6(8):743-9 (2000) Abstract.
Dong, Z., et al., “Expression of Membrane-Type Matrix Metalloproteinases 4, 5, and 6 in Mouse Corneas Infected withP. aeruginosa,” Invest Opthalmol Vis Sci—42(13):3223- (2001) Abstract.
Duchrow, M., et al., “Assessment of Proliferative Activity in Colorectal Carcinomas by Quantitative Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR),”Cancer Invest.—19(6):588-96 (2001) Abstract.
Dyer, J., et al., “Molecular Characterisation of Carbohydrate Digestion and Absorption in Equine Small Intestine,”Equine Vet J.—34(4):349-58 (2002) Abstract.
Egwuagu, C.E., et al., “Suppressors of Cytokine Signaling Proteins are Differentially Expressed in Th1 and Th2 Cells: Implications for Th Cell Lineage Commitment and Maintenance,”J Immunol.—168(7):3181-7 (2002) Abstract.
El-Ghrably, I.A., et al., “Intravitreal Invading Cells Contribute to Vitreal Cytokine Milieu in Proliferative Vitreoretinopathy,”Br J Opthalmol.—85(4):461-70 (2001) Abstract.
Eleore, L., et al., “Modulation of the Glutamatergic Receptors (AMPA and NMDA) and of Glutamate Vesicular Transporter 2 in the Rat Facial Nucleus after Axotomy,”Neuroscience—136(1):147-60 (2005) Abstract.
Forsberg, H., et al., “Altered Levels of Scavenging Enzymes in Embryos Subjected to a Diabetic Environment,”Free Radic Res.—24(6):451-9 (1996) Abstract.
Freyschuss, B., et al., “Induction of the Estrogen Receptor by Growth Hormone and Glucocorticoid Substitution in Priminary Cultures of Rat Hepatocytes,”Endocrinology—133(4):1548-54 (1993) Abstract.
Fu, K., et al., “Cyclin D1-Negative Mantle Cell Lymphoma: A Clinocopathology Study Based on Gene Expression Profiling,”Blood—106(13):4315-21 (2005) Abstract.
Fuchs, A.R., et al., “Oxytocin Receptors in Bovine Cervix: Distrubution and Gene Expression During the Estrous Cycle,”Biol Reprod.—54(3):700-8 (1996) Abstract.
Furuta, J., et al., “Silencing of the Thrombomodulin Gene in Human Malignant Melanoma,”Melanoma Res.—15(1):15-20 (2005) Abstract.
Futcher, B., et al., “A Sampling of the Yeast Proteome,”Mol Cell Biol.,—19(11):7357-68 (1999) Abstract.
George, J., et al., “Pre-translational Regulation of Cytochrome P450 Genes is Responsible for Disease-Specific Changes of Individual P450 Enzymes Among Patients with Cirrhosis,”Biochem Pharmacol.—49(7):873-81 (1995) Abstract.
Giroux, M., et al., “Cyclooxygenase-2 Expression in Macrophages: Modulation by Protein Kinase C-alpha,”J immunol.—165(7):3985-91 (2000) Abstract.
Gnatenko, D.V., et al., “Transcript Profiling of Human Platelets Using Microarray and Serial Analysis of Gene Expression,”Blood—101(6):2285-93 (2003) Abstra

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Secreted and transmembrane polypeptides and nucleic acids... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Secreted and transmembrane polypeptides and nucleic acids..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Secreted and transmembrane polypeptides and nucleic acids... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3896247

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.