Secosteroids, and method for producing same

Details Secosteroids, and method for producing same Secosteroids, and method for producing same

1996-07-25

1998-06-09

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing at least three carbocyclic rings

435146, 435148, C12P 1500, C12P 742, C12P 726

Patent

active

057632340

ABSTRACT:
A fortified enzyme preparation of the gorgonian Pseudopterogorgia americana has been developed which efficiently transforms a variety of sterols to their 9(11)-secosteroid derivative in high yield. NAD, NADP, and glutamate dehydrogenase are key additives in this enzymatic conversion. In addition to naturally-occurring metabolites, novel secosteroids have been prepared.

REFERENCES:
Ochi, M. et al. (1991) "Calicoferols A and B, Two Novel Secosterols Possessing Brine-Shrimp Lethality from the Gorgonian Calicogorgia sp." Chemistry Letters, pp. 427-430.
D'Auria, M.V., L. Minale, R. Riccio (1993) "Isolation and Synthesis Of A New 9.11-Secosterol From The Sponge Spongia Officinalis" Journal of Natural Products 57(9):1200-1226.
He, Haiyin et al. (1995) "New Antiproliferative And Antiflammatory 9,11-Secosterols from the Gorgonian Pseudopterogorgia sp." Tetrahedron 51(1):51-58 Jan.-Feb.
D'Auria, Maria Valeria, Luigi Minale and Raffaele Riccio (1993) "Polyoxygenated Steroids of Marine Origin" Chem. Rev. 93:1839-1895.

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