Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Patent
1996-07-30
1998-01-20
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
435234, 4352535, C12N 900, C12N 992, C12N 120
Patent
active
057100322
ABSTRACT:
Secondary-metabolite biosynthesis genes from actinomycetes, method of isolating them, and their use.
The invention concerns secondary-metabolite biosynthesis genes from actinomycetes, a method of isolating secondary-metabolite and, in particular, 6-deoxy-sugar bio-synthesis genes, from actinomycetes using the gene probes strD, strE, strL and strM gene probes from Streptomyces griseus DSM40236, and structurally related genes, as gene probes for detecting the genes snot (coding for amphotheronolide B-dTDP-D-mycosaminyl transferase), snoD (coding for dTDP-D-glucose synthase) and snoM (coding for dTDP-4-keto-6-deoxy-D-glucose isomerase), or one or more secondary-metabolite biosynthesis genes from actinomycetes. The invention also concerns the use of secondary-metabolite biosynthesis genes thus isolated.
REFERENCES:
patent: 4081327 (1978-03-01), Chibata et al.
patent: 4137126 (1979-01-01), Weber
patent: 4191810 (1980-03-01), Yoshikazu et al.
patent: 5122595 (1992-06-01), Ortega et al.
Brau Barbara
Piepersberg Wolfgang
Sichel Petra
Hobbs Lisa J.
Hoechst Aktiengesellschaft
Patterson Jr. Charles L.
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