Secondary antibodies against complexes of small molecules and bi

Details Secondary antibodies against complexes of small molecules and bi Secondary antibodies against complexes of small molecules and bi

1987-04-28

1990-09-11

Hill, Jr., Robert J.

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

Separation of immune complex from unbound antigen or antibody

436507, 436518, 436538, 436545, 436548, 530387, G01N 33537

Patent

active

049563033

ABSTRACT:
A secondary antibody capable of stabilizing the binding of a small molecule to its binding protein is described which secondary antibody is capable of binding said binding protein in the presence of an in the absence of the small molecule but is not capable of binding said small molecule in the absence of binding protein. Such antibodies may be obtained by forming a complex between a small molecule and its binding protein, using the complex to raise antibodies and selecting the antibodies. The antibodies may be used in competitive assays in which it is desired to improve the binding of a small molecule or labelled small molecule to its binding protein.

REFERENCES:
patent: 3839153 (1974-10-01), Schuars
patent: 3933997 (1976-01-01), Hersh
patent: 4298592 (1981-11-01), Lin
patent: 4544640 (1985-10-01), Soma
patent: 4606855 (1986-08-01), Deutsch
patent: 4659678 (1987-04-01), Forrest
International Publication No. WO 85/04422.
International Publication No. WO 86/00140, Self, 1/3/86.
Nemazee, D. A. et al., "Enhancing Antibody: A Novel Component of the Immune Response", PNAS, vol. 79, pp. 3828-3832, 1982.

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