Secondary amines, their preparation and use in pharmaceutical co

Details Secondary amines, their preparation and use in pharmaceutical co Secondary amines, their preparation and use in pharmaceutical co

1983-03-10

1984-10-23

Evans, J. E.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

560 34, 560 42, 562430, 562439, 562451, 564 50, 564 99, 564157, 564165, 424309, 424319, 424320, 424322, 424324, A61K 3124, A61K 31195

Patent

active

044788495

ABSTRACT:
The compounds of the formula (II): ##STR1## and their pharmaceutically acceptable salts wherein R.sub.1 is a hydrogen, fluorine or chlorine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R.sub.2 is a hydrogen, fluorine or chlorine atom or a hydroxyl group; R.sub.3 is a hydrogen or chlorine atom or a hydroxyl group; R.sub.4 is a carboxylic acid group or a salt, ester or amide thereof; R.sub.5 is a hydrogen, chlorine or fluorine atom or a methyl, methoxyl or hydroxyl group or a carboxylic acid group or a salt, ester or amide thereof; R.sub.6 is a hydrogen atom or a methyl, or propyl group; X is an oxygen atom or a bond; and Y is an alkylene group of up to 6 carbon atoms or a bond have been found to possess anti-obesity and/or antihyperglycaemic activity.

REFERENCES:
patent: 4086272 (1978-04-01), Cox et al.
patent: 4146638 (1979-03-01), Renth et al.
patent: 4329358 (1982-05-01), Ainsworth et al.
patent: 4385066 (1983-05-01), Ainsworth et al.

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