Second generation monoclonal antibodies having binding specifici

Details Second generation monoclonal antibodies having binding specifici Second generation monoclonal antibodies having binding specifici

1990-07-02

1996-04-30

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 72, 435 71, 435 721, 435 79, 4351722, 43524027, 436548, 436 63, 436 64, 436813, 5303888, 53038885, 5303877, 424 9341, 4241411, 4241561, 4241781, 4241741, 424 149, G01N 33574, G01N 3353

Patent

active

055124437

ABSTRACT:
The present invention relates to second generation monoclonal antibodies having binding specificity to a tumor associated glycoprotein having an approximate molecular weight of >10.sup.6 d ("TAG-72") and human carcinomas and methods for employing the same. Hybridomas producing such antibodies have been prepared.

REFERENCES:
patent: 4361544 (1982-11-01), Goldenberg
patent: 4522918 (1985-06-01), Schlom et al.
patent: 4565687 (1986-01-01), Khazaeli et al.
patent: 4612282 (1986-09-01), Schlom et al.
Harris, W. J., "Therapeutic antibodies--the coming of age," TIBTECH, vol. 11, pp. 42-44, Feb. 1993.
Schlom, J., et al., Cancer Res., vol. 52, 1067-1072, Mar. 1, 1992.
Waldmann, T. A., Science, vol. 252, pp. 1657-1662, 21 Jun. 1991.
Schlom et al, Cancer Res. (Suppl.). 50:820-827, 1990.
Muraro et al, Cancer Res. 48:4588-4596, 1988.
Thor et al, Cancer Res. 46:3118-3124, 1986.
Molinolo et al. Cancer Res. 50:1291-98, 1990.
Weinstein et al, 1986 on Site Specific Drug Delivery. 81-91.
Weinstein et al, 1987. Ann. N. Y. Acad. Sci. 507:199-210.
Fujimori et al. Cancer Res. 49:5656-5663, 1989.
Larson et al. Protocol, Phase I Evaluation of . . . Total of 35 Pages.
Johnson, V. G. et al, Cancer Res., vol. 46, 850-857, (Feb., 1986).
Lundy, J. et al, Cancer, vol. 57, 503-509, (1986).
Levy, R. et al, "Tumor Therapy with Monoclonal Antibodies" in Monoclonal Antibodies in Approaches to Tumor Immunology, a Minisymposium Summary. Federation Proceedings vol. 42, No. 9 pp. 2650-2659 (1982).

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