Secoaporphine compound on arrhythmia

Details Secoaporphine compound on arrhythmia Secoaporphine compound on arrhythmia

1994-01-26

1997-01-14

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514609, 564105, 564379, A61K 31135, C07C21760

Patent

active

055940331

ABSTRACT:
Novel secoaporphine compounds having the formula I ##STR1## wherein a) R.sub.1, R.sub.2 and R.sub.3, R.sub.4 are each methyl group; or b) R.sub.1, R.sub.2, and R.sub.4 are each methyl group; R.sub.3 is benzyl, ethyl or allyl; or c) R.sub.1, R.sub.2, and R.sub.3 are each hydrogen, R.sub.4 is methyl; or d) R.sub.1 and R.sub.2 are each hydrogen, R.sub.3 is benzyl, R.sub.4 is methyl; or e) R.sub.1 and R.sub.2 are each hydrogen, R.sub.3 is cyano, R.sub.4 is methyl group, and a salt thereof with a pharmaceutically acceptable acid. The novel compounds are useful in the treatment of arrhythmia.

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Bremner et al, Chemical Abstracts, vol. 88 (1978) 19181.
Smissman et al, Chemical Abstracts, vol. 73 (1970) 82368.
T. Kametani et al., "Biogenetic Type Syntheses of Aporphine Alkaloids, Isoboldine and Glaucine", Tetrahedron, vol. 25, pp. 3667 to 3673, published prior to or on Dec. 31, 1969.

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