Seco-mevinic acid derivatives useful as antihypercholesterolemic

Details Seco-mevinic acid derivatives useful as antihypercholesterolemic Seco-mevinic acid derivatives useful as antihypercholesterolemic

1991-05-01

1993-02-23

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549283, 549290, 549374, 549375, 549369, 549370, 549 60, 549373, 556440, 544 60, 544148, 544374, 544336, 544335, 540575, 546152, 546176, 546181, 546207, 546268, 548203, 548204, 548517, 5483111, 5483351, 548214, 548247, 5483355, C07D31102, C07D31906, C07F 702, C07F 708

Patent

active

051891808

ABSTRACT:
Seco-mevinic acid derivatives are provided which have the structure ##STR1## including all stereoisomers thereof, wherein Z is ##STR2## R is H, alkali metal or lower alkyl, R.sup.1 is H, lower alkyl, aryl, lower alkoxy, cycloalkyl, heteroaryl, aralkyl, heteroaralkyl or heterocyclic; R.sup.2 is lower alkyl, cycloalkyl or aralkyl, and X is O or NR.sup.5 wherein R.sup.5 is H or lower alkyl, and are HMG CoA reductase inhibitors and thus are useful as antihypercholesterolemic agents and in treating atherosclerosis.
New intermediates for preparing the above seco-mevinic acid derivatives are also provided.

REFERENCES:
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patent: 4137322 (1979-01-01), Endo et al.
patent: 4375475 (1983-03-01), Willard et al.
patent: 4873345 (1989-10-01), Duggan
patent: 5025017 (1991-06-01), Karanewsky
Tetrahedron Letters, vol. 29, No. 8, 929-930, 1988.
C. H. Heathcock et al, "Synthesis and Biological Evaluation of a Monocyclic, Fully Functional Analogue of Compactin," J. Med. Chem. 1989, 32, 197.

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