Seco-cholestane derivatives and methods of making the same

Details Seco-cholestane derivatives and methods of making the same Seco-cholestane derivatives and methods of making the same

1998-09-22

2000-01-04

Lambkin, Deborah C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549268, 549280, 549299, 558419, A61K 31335, C07D31306

Patent

active

060110589

ABSTRACT:
The present invention is directed to novel seco-cholestane derivatives, as well as to pharmaceutical compositions thereof, and methods of making the same. More particularly, the invention relates to C5- and C8-substituted seco-cholestane derivatives. The compounds of the invention can exhibit CDC25 phosphatase inhibition properties and anti-cancer activity.

REFERENCES:
patent: 4732897 (1988-03-01), Cainelli et al.

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