SecA gene of mycobacterium tuberculosis and related methods and

Details SecA gene of mycobacterium tuberculosis and related methods and SecA gene of mycobacterium tuberculosis and related methods and

1997-02-14

1999-03-23

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4353201, 4352523, 435 691, 536 231, 530350, C12N 500, C12N 1500, C12P 2106, C07H 1700

Patent

active

058858288

ABSTRACT:
An isolated nucleic acid encoding a SecA protein of M. tuberculosis is provided. This nucleic acid can be a native coding sequence for the SecA protein of M. tuberculosis. A specific example of the isolated nucleic acid is one that encodes a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:2. An isolated fragment of the secA gene that is specific for M. tuberculosis is provided. A purified SecA protein of Mycobacterium tuberculosis is provided. The purified SecA protein of Mycobacterium tuberculosis comprises the polypeptide having the sequence set forth in the Sequence Listing as SEQ ID NO:2. Fragments of the M. tuberculosis SecA protein are provided. A purified mutant SecA protein of Mycobacterium tuberculosis is provided. The invention provides purified mutant M. tuberculosis expressing the mutant SecA protein of the invention. The invention also provides methods of screening for putative M. tuberculosis virulence factors translocated by the SecA protein.

REFERENCES:
Sadaie et al 1991 Gene: 98 : 101-105 Overholf et al 1991 Mol. Gen Genet 228 : 417-423.
Takamatsu et al 1992 J Bacteriol. 174(13):4308-4316.

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