Search for cancer markers by a screening method

Details Search for cancer markers by a screening method Search for cancer markers by a screening method

2011-01-11

2011-01-11

Tsang, Cecilia (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

Reexamination Certificate

active

07868136

ABSTRACT:
The present invention relates to a method of concentrating low molecular weight peptides in the supernatant of serum-free cultured cells, said method comprising allowing the peptides to bind to a strong cation exchanger under an acid condition, and eluting them under an alkali condition to concentrate the peptide.Furthermore, peptides having the amino acid sequence as set forth in SEQ ID NO: 1 or 2, and a method of screening cancer markers using antibody to these peptides, are disclosed.

REFERENCES:
patent: 3592836 (1971-07-01), Leverkusen et al.
patent: 5843686 (1998-12-01), Zain et al.
patent: 6346606 (2002-02-01), Mollenhauer et al.
patent: 6670195 (2003-12-01), Ghiso et al.
patent: 55-64799 (1980-05-01), None
patent: 58-89196 (1983-05-01), None
patent: WO 91/04490 (1991-04-01), None
patent: WO 98/30687 (1998-07-01), None
patent: WO 99/25825 (1999-05-01), None
patent: WO 00/55350 (2000-09-01), None
patent: WO 00/58357 (2000-10-01), None
patent: WO 00/71671 (2000-11-01), None
patent: WO 02/42733 (2002-05-01), None
Pharmacia Biotech, 1997 catalog, TOC and p. 363.
K. Gevaert et al., “Protein indentification methods inproteomics”,Electrophoresis, 2000, vol. 21, pp. 1145-1154.
Ball et al., “An integrated approach utilizing artificial neural networks and SELDI mass spectrometry for the classification of human tumours and rapid identification of potential biomarkers,” Bioinformatics, Mar. 2002, vol. 18, No. 3, pp. 395-404.
Chapman, K., “The ProteinChip® Biomarker System from Ciphergen Biosystems: a novel proteomics platform for rapid biomarker discovery and validation,” Biochemical Society Transactions, Apr. 2002, vol. 30, No. 2, pp. 82-87.
Certification, Apr. 26, 2002.
Abstracts of congress papers, Mar. 5, 2002.
Request for certification, May 24, 2002.
Li et al., “Proteomics and Bioinformatics Approaches for Identification of Serum Biomarkers to Detect Breast Cancer,” Clinical Chemistry, Aug. 2002, vol. 48, No. 8, pp. 1296-1304.
Petricoin III et al., “Use of proteomic patterns in serum to identify ovarian cancer,” The Lancet, Feb. 16, 2002, pp. 572-577.
Sato et al., “Mass spectrometric high-throughput analysis of serum-free conditioned medium from cancer cell lines,” Cancer Letters, Sep. 20, 2001, vol. 170, No. 2, pp. 153-159.
Sato et al., “Peptide differential display of serum-free conditioned medium from cancer cell lines,” Cancer Letters, Feb. 25, 2002, vol. 176, No. 2, pp. 199-203.
Von Eggeling et al., “Mass spectrometry meets chip technology: A new proteomic tool in cancer research?”, Electrophoresis, Aug. 2001, vol. 22, No. 14, pp. 2898-2902.
Mollenhauer et al., “DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours”, Nature Genetics, Sep. 1997, vol. 17, No. 1, pp. 32-39.
Rosty et al., “Identification of Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I as a Biomarker for Pancreatic Ductal Adnocarcinoma by Protein Biochip Technology”, Cancer Research, Mar. 2002, vol. 62, No. 2, pp. 1868-1875.
Sasaki et al, “Peptidomics-based Approach Reveals the Secretion of the 29-Residue COOH-Terminal Fragment of the Putative Tumor Suppressor Protein DMBT1 from Pancreatic Adenocarcinoma Cell Lines”, Cancer Research, Sep. 2002, vol. 62, No. 17, pp. 4894-4898.
Scopes, Robert K., “Protein Purification: Principles and Practice, ” 2ndEdition (1987), pp. 100-118.

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