Seamless capsule and method of manufacturing the same

Details Seamless capsule and method of manufacturing the same Seamless capsule and method of manufacturing the same

1996-12-03

1999-03-16

Wu, David W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424452, 424456, 424457, 424458, A61K 948

Patent

active

058826807

ABSTRACT:
There are provided a seamless capsule containing therein a large quantity of an active ingredient which is difficultly soluble in water and oil and a method of manufacturing the seamless capsule. Encapsulating liquid 1, in which the active ingredient is difficultly soluble in water and oil is suspended in oil as particles each having the mean particle diameter of less than 20 .mu.m, is enclosed in hydrophilic outer shells. This seamless capsule SC is manufactured in such a manner that from a multiple nozzle 7, suspension, in which the active ingredient which is difficultly soluble in water and oil is dispersed in oil and the active ingredient in thus obtained dispersion is pulverized to obtain particles each having the mean particle diameter of less than 20 .mu.m, as encapsulating liquid 1, and aqueous liquid of a shell forming substance, as outer shell forming liquid 3, are dropped into hardening liquid 10.

REFERENCES:
patent: 5478508 (1995-12-01), Suzuki et al.
patent: 5500224 (1996-03-01), Vranckx et al.
patent: 5595757 (1997-01-01), Kiefer et al.
patent: 5650232 (1997-07-01), Glenn et al.
Translation of JP 59-190, 916, Oct. 1984.
Translation of JP 53-39, 139, Oct. 1978.

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