Scytophycins-producing Scytonema pseudohofmanni microorganisms

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Algae – media therefor

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435124, 435946, C12N 112, C12R 189, C12P 1708

Patent

active

052815331

ABSTRACT:
Scytophycins A, B, C, D and E, an aldehyde and alcohol derivative of scytophycin B and the specified alkanoyl and benzoyl esters of scytophycins A, B, C, D and E and the B derivatives (scytophycin compounds) are novel antineoplastic and antifungal agents. Antifungal compositions containing a scytophycin compound and methods of inhibiting fungi, especially plant pathogenic fungi, using these compositions are included. A method for producing the scytophycin complex, comprising scytophycins A, B, C, D and E, using a new strain of the blue-green alga Scytonema pseudohofmanni, and a biologically purified culture of the alga are also provided.

REFERENCES:
patent: 4342751 (1982-08-01), Moore et al.
patent: 4626271 (1986-12-01), Gleason
S. Carmely et al., "Structure of Swinholide-A, A New Macrolide From the Marine Sponge Theonella swinhoei", Tetrahedron Letters 1985, 511-514.
R. E. Moore in Marine Natural Products: Chemical and Biological Perspectives, P. J. Scheuer, ed., vol. IV, pp. 1-52, Academic Press, New York (1981).
R. E. Moore, "Toxins from Blue-Green Algae", BioScience 27 (12), 797-802.
R. E. Moore et al., "Toxins from Cyanophytes Belonging to the Scytonemataceae," Pure & Appl. Chem. 58 (2), 263-271 (1986).
J. A. Roesener et al., "Ulapualide A and B, Extraordinary Antitumor Macrolides from Nudibranch Eggmasses," J. Am. Chem. Soc. 1986, 108, 846-847.
S. Matsunaga et al., "Kabiramide C, a Novel antifungal Macrolide from Nudibranch Eggmasses," J. Am. Chem. Soc. 1986, 108, 847-849.
Chemical Abstracts (1987) 106:153049e, Moore, et al., "Scytophycins, potent cytotoxic macrolides from blue-green alga".
M. Ishibashi, et al., J. Org. Chem. (1986) 51, 5300-5306, "Scytophycins, Cytotoxic and Antimicotic Agents from the Cyanophyte Scytonema pseudohofmanni".
M. Kashiwagi et al., J. Pharm. Sciences 69 (6), 735-738 (1980), "Antineoplastic Evaluation of Pacific Basin Marine Algae".

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Scytophycins-producing Scytonema pseudohofmanni microorganisms does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Scytophycins-producing Scytonema pseudohofmanni microorganisms, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Scytophycins-producing Scytonema pseudohofmanni microorganisms will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-727283

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.