SCTLA-4 gene and product

Details SCTLA-4 gene and product SCTLA-4 gene and product

1997-02-21

2000-08-22

Saunders, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 536 231, C12P 2106

Patent

active

061070564

ABSTRACT:
The invention identifies a novel mRNA transcript in man, mouse and the rat which encodes a CTLA-4 molecule which lacks the transmembrane region, and thus represents a native soluble form of CTLA-4. This shortened CTLA-4 transcript and its predicted polypeptide product are designated sCTLA-4. The nucleotide and the predicted amino acid sequences encoding the human, rat and mouse sCTLA-4 molecules are provided.

REFERENCES:
patent: 5434131 (1995-07-01), Linsley et al.
Gerstmayer et al, FEBS Letters, 407, 63-68, 1997.

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