Screens for mutations in the anti-proliferation domain of human

Details Screens for mutations in the anti-proliferation domain of human Screens for mutations in the anti-proliferation domain of human

1998-05-15

1999-09-14

Feisee, Lila

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 231, 536 235, 530324, 530300, C12Q 168, C12N 1510, C12N 1512, C07K 1482

Patent

active

059521791

ABSTRACT:
A domain of Bcl-2 that suppresses apoptosis by allowing cell survival permits cell proliferation when mutated. The wild type domain includes amino acid residues 51 to 97 (SEQ ID NO: 13) of Bcl-2. Peptides including the domain and nucleotides encoding the domain are useful in molecular screening of human tumors for the presence of mutations that allow proliferation of cells that were otherwise marked for apoptosis. The peptides are also useful to screen for proteins that play a role in the modulation of cellular proliferation.

REFERENCES:
Z. Songyang et al., "SH2 Domains Recognize Specific Phosphopeptide Sequences", Cell, 72:767-778 (1993).
J. Saras et al., "Characterization of the Interactions between PDZ Domains of the Protein-tyrosine Phosphatase PTPL1 and the Carboxyl-terminal Tail of Fas", J. Bio. Chem., 272:20979-20981 (1997).

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