Screening vaccines and immunization process

Details Screening vaccines and immunization process Screening vaccines and immunization process

1982-03-01

1984-12-25

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

424 85, 424 87, 436548, A61K 39395, A61K 3942, G01N 3354, G01N 3356

Patent

active

044903588

ABSTRACT:
Mammals are vaccinated against infectious organisms and polypeptides are screened for utility as vaccines by a complementing set of monoclonal antibodies, the first of which antibodies binds specifically to the site on the organism which itself binds specifically to a receptor on a host cell of the mammal, and the second of which binds specifically to the first. Vaccination is done with the second antibody alone, and screening is done by determining whether the polypeptide binds to the first antibody.

REFERENCES:
Nisonoff et al., Clinical Immunology and Immunopathology, vol. 21, pp. 397-406 (1981).
Moshly-Rosen et al., FEBS Letters, vol. 106, 389-392 (1979).
Letvin et al., The J. of Immunology, vol. 127, 2334-2339 (1981).
Nepom et al., J. Exp. Med., vol. 155, 155-167 (1982).

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