Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2007-03-20
2007-03-20
Crouch, Deborah (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S008000
Reexamination Certificate
active
10219590
ABSTRACT:
The present invention provides mice having reduced CAR receptor activity and mice expressing a human CAR receptor. These mice are useful in screening methods to identify compounds that modulate CAR receptor activity, compounds likely to have CAR-mediated toxicity, and analogs of these compounds with less potential toxicity.
REFERENCES:
patent: 5710017 (1998-01-01), Moore et al.
patent: 6579686 (2003-06-01), Collins et al.
patent: 6693226 (2004-02-01), McNeish
patent: 6921845 (2005-07-01), Amson et al.
patent: 6987211 (2006-01-01), Soreq
patent: 2002/0152479 (2002-10-01), Lehmann et al.
patent: WO-99/15555 (1999-04-01), None
patent: WO-00/47735 (2000-08-01), None
patent: WO-01/51045 (2001-07-01), None
Cameron E.R. (1997) Recent Adavnces in Transgenic Technology. Molecular Biotechnology. 7:253-265.
Bowie et al. (1990) Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions. Science. 247:1306-1310.
Ngo et al. (1994) The Protein Folding Problem and Tertiary Structure Predicticnj, Merz er (ed.), pp. 437&492-495.
Houdebine. (2000) Transgenic animal bioreactors. Transgenic Research. 9:305-320.
Kolb et al. (1999) Insertion of a foriegn gene into the beta-casein locus by Cre-mediated site-specific recombination. Gene 227:21-31.
Lariviere et al. (2000) Transgenic Studies of Pain and Analgesia:Mutation or Background Genotype. J. of Pharm and Exp. Therap. 297:467-473.
Leiter et al. (2002) Mice with targeted gene disruptions or gene insertions for diabetes research:problems, pitfalls, and potential solutions. Diabetologia 45:296-308.
Thiron et al. (2006) Human Gene Therapy 17:193-205.
Burk et al. (2005) Biol. Chem. 386:503-513.
Sigmund, C., (2000) Arterioscler. Thromb. Vasc. Biol., p. 1425-1429.
Baes et al., “A New Orphan Member of the Nuclear Hormone Receptor Superfamily that interacts with a Subset of Retinoic Acid Response Elements,” Molecular And Cellular Biology 14(3):1544-1552 (1994).
Bornheim, “Effect of Cytochrome P450 Inducers on Cocaine-mediated Hepatoxicity,” Toxicology And Applied Pharmacology 150:158-165 (1998).
Blumberg et al., “SXR, a Novel Steroid and Xenobiotic-Sensing Nuclear Receptor,” Genes Dev., 12:3195-3205 (1998).
Carthew et al., “The Quantitative Distinction of Hyperplastic in Hepatomegaly Induced in the Rat Liver by Phenobarbital,” Toxicological Science 44:46-51 (1998).
Choi et al., “Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR,” The Journal of Biological Chemistry, 272:23565-23571 (1997).
Code et al., “Human Cytochrome P4502B6: Interindividual Hepatic Expression, Substrate Specificity, and Role in Procarcinogen Activation,” Drug Metabolism And Disposition 25(8):985-993 (1997).
Cunningham, “Role of Increased DNA Replication in the Carcinogenic Risk of Nonmutagenic Chemical Carcinogens,” Mutation Research 365:59-69 (1996).
Heubel et al., “Differences between Induction Effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]Benzene and Phenobarbitone,” Biochemical Pharmacology 38:1293-1300 (1989).
Honkakoski et al., “Characterization of Phenobarbital-inducible Mouse Cyp2b10 Gene Transcription in Primary Hepatocytes,” The Journal of Biological Chemistry 271(16):9746-9753 (1996).
Honkakoski et al., “The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene,” Molecular And Cellular Biology 18(10):5652-5658 (1998).
Jones et al., “The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor that has Diverged during Evolution,” olecular Endocrinology 14(1):27-39 (2000).
Kliewer et al., “An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway,” Cell 92:73-82 (1998).
Lehmann et al., “The Human Orphan Nuclear Receptor PXR Is Activated by Compounds that Regulate CYP3A4 Gene Expression and Cause Drug Interactions,” J. Clin. Invest. 102(5):1016-1023 (1998).
Moore et al., “Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands,” The Journal Of Biological Chemistry 275(20):15122-15127 (2000).
Pellinen et al., “Regenerative changes in Hepatic Morphology and Enhanced Expression of CYP2B10 and CYP3A During Daily Administration of Cocaine,” Hepatology 23(3):515-523 (1996).
Poland et al., “1,4-Bis[2-(3,5-Dichloropyridyloxy)]Benzene, a Potent Phenobarbital-like Inducer of Microsomal Monooxygenase Activity,” Molecular Pharmacology 18:571-580 (1980).
Robinson et al., “Genetic Expression of Aryl Hydrocarbon Hydroxlase Induction. Presence or Absence of Association with Zoxazolamine, Diphenylhydantoin, and Hexobarbital Metabolism,” Molecular Pharmacology 10:484-493 (1974).
Selim et al., “Hepatotoxicity of Psychotropic Drugs,” Hepatology 29(5):1347-1351 (1999).
Shimada et al., “Interindividual Variations in Human Liver Cytochrome P-450 Enzymes Involved in the Oxidation of Drugs, Carcinogens and Toxic Chemicals: Studies with Liver Microsomes of 30 Japanese and 30 Caucasians,” The Journal Of Pharmacology And Experimental Therapeutics 270(1):414-423 (1994).
Sueyoshi et al., “The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene,” The Journal Of Biological Chemistry 274(10):6043-6046 (1999).
Traber et al., “Differential Regulation of Cytochrome P-450 Genes along Rat Intestinal Crypt-villus Axis,” Am. J. Physiol. 263:G215-223 (1992).
Tzameli et al., “The Xenobiotic Compound 1,4-Bis[2-(3,5-Dichloropyridyloxy)]Benzene Is an Agonist Ligand for the Nuclear Receptor CAR,” Molecular And Cellular Biology 20(9):2951-2958 (2000).
Waxman, “P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR,” Archives of Biochemistry And Biophysics 369(1):11-23 (1999).
Zhang, Jun, et al.; Modulation of Acetaminophen-induced Hepatotoxicity by the Xenobiotic Receptor CAR; Science, vol. 298, pp. 422-424, Oct. 11, 2002.
Huang, Wendong, et al.: Induction of bilirubin clearance by the constitutive androstane receptor (CAR); PNAS 100(7):4156-4161, Apr. 1, 2003.
Baes et al., “A New Orphan Member of the Nuclear Hormone Receptor Superfamily That Interacts with a Subset of Retinoic Acid Response Elements,”Mol. Cell. Biol., 14(3): 1544-1552, 1994.
Garcia-Vallve et al., “Nuclear Receptors, Nuclear-Receptor Factors, and Nuclear-Receptor-like Orphans Form a Large Paralog Cluster inHomo sapiens,” Mol. Biol. Evol., 15(6): 665-682, 1998.
Hardouin et al., “Mouse models for human disease,”Clin. Genet., 57: 237-244, 2000.
Hayashi et al., “Liver enriched transcription factors and differentiation of hepatocellular carcinoma,”J. Clin. Pathol: Mol. Pathol., 52: 19-24, 1999.
Kumar et al., “The structure of the nuclear hormone receptors,”Steroids, 64: 310-319, 1999.
Moore et al., “Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands,”J. Biol. Chem., 275(20): 15122-15127, 2000.
Tenbaum et al., “Nuclear Receptors: Structure, Function, and Involvement in Disease,”Int. J. Biochem. Cell Biol.,29(12): 1325-1341, 1997.
Tzameli et al., “The Xenobiotic Compound 1,4-Bis[2-(3,5-Dichloropyridyloxy)]Benzene Is an Agonist Ligand for the Nuclear Receptor CAR,”Mol. Cell. Biol., 20(9):2951-2958, 2000.
Wei et al., “The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism,”Nature, 407: 920-923, 2000.
West et al., “Mouse Genetics/Genomics: An Effective Approach for Drug Target Discovery and Validation,”Med. Res. Rev., 20(3): 216-230, 2000.
Oliver, J.D. et al. Receptor-mediated hepatocarcinogenesis: role of hepatocyte proliferation and apoptosis. Pharmacology & Toxicology 2002, vol.
Moore David D.
Wei Ping
Baylor College of Medicine
Crouch Deborah
Fulbright & Jaworski LLP
Lieto Louis D
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