Screening systems

Details Screening systems Screening systems

1991-07-24

1999-03-23

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 435 71, 435 29, 435 76, 435455, 435456, 435465, 435467, 435325, 435353, 4353201, 536 231, 536 232, 536 235, 536 241, C12Q 168, C12Q 170, C12N 510, C12N 1586

Patent

active

058857699

ABSTRACT:
Transformed cell lines containing a reporter gene operatively linked to a genetic control element that is responsive to growth factor-stimulated cell proliferation and/or oncogene-mediated neoplastic transformation are provided. Also provided are methods for using such transformed cell lines to screen for growth factor antagonists and/or antineoplastic agents.

REFERENCES:
Kedar et al. "Transfected human B-polymerase..." Mol Cell. Bio 10: 3852-3856 1990.
Lenardo et al. "Suppression of MHC class Z..." EMBO 8: pp. 3351-3355 1989.
Avvedimento, V. et al, "Neoplastic transtormation inactivate..." Proc. Natl. Mod. Sci. vol. 85, pp. 1744-1748 Mar. 1988.
Bernstem et al, "Alzljun Farction is differentially..." Science vol. 244 pp. 566-569.
Shindo-Okoda et al. "Permanent Conversion of HlH3T3..." in Antlmutogives L Anticacogives... ed. Kuroda et al. pp.309-,312, 1990.
Nakaro et al. "Transcriptional regulatory..." Gene 99 , pp. 285-289 , 1991.
An et al., Mol., Cell. Biol. 2: 1628 (1982).
Bishop et al., Ann, Rev. Biochem. 52: 301 (1983).
Corjay et al., J. Biol. Chem. 264: 10501 (1989).
DeWet et al., Mol. Cell. Biol. 7:725 (1987).
Franza et al., Cancer 1:137 (1984).
Gorman et al., Mol. Cell. Biol. 2:1044 (1982).
Henthorn et al., Proc. Natl. Acad. Sci. USA 85:6342 (1988).
Kumar et al., Biochemistry 28:4027 (1989).
Kumar et al., in Cytoskeletal Proteins in Tumor Diagnosis, 1989, Weber et al., Eds., Cold Spring Harbor Press, pp. 91-97.
Leavitt et al., Nature 316:840 (1985).
Owen et al., Mol. Cell. Biol. 10:1 (1990).
Owens et al., J. Cell Biol. 102:343(1988).
Pollack et al., Proc. Natl. Acad. Sci. USA 72:994 (1975).
Reddy et al., J. Biol. Chem. 265:1683 (1990).
Searle et al., Mol. Cell. Biol. 5:1480 (1985).
Shumperli et al., Proc. Natl. Acad. Sci. USA 79:257. (1982).
Topp, Virology 113:408 (1981).
Tsang et al., Proc. Natl. Acad. Sci. USA 85:8598 (1988).
Weinberg et al., Science 230:770 (1985).
Whyte et al., Nature 334:124 (1988).
R&D Synapse, vol., 3 No. 4, Apr. 1990, pp. 5-6.

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